Edward E. McKee
Biochemistry, Cell and Molecular Biology, and Medical Genetics
Edward McKee, Ph.D., joined CMU College of Medicine in 2011 as professor and chair of Foundational Sciences. He received Bachelor of Science degrees in biology and biochemistry from Pennsylvania State University. He received his Ph. D. in physiology from the Penn State Milton S. Hershey Medical Center College of Medicine studying the regulation of protein metabolism in the perfused rat heart. Following post-doctoral fellowships at the University of Connecticut Health Science Center and the University of Colorado, he accepted a faculty position in Biochemistry at the Rosalind Franklin University of Medicine and Science/The Chicago Medical School. While there, he studied the regulation of mitochondrial biogenesis in yeast and mammalian tissues and helped design and direct a medical school course in Molecular and Cellular Biology.
He was then appointed associate professor of Biochemistry and Molecular Biology at Indiana University School of Medicine-South Bend where he directed and taught biochemistry, molecular biology and medical genetics. He introduced Team-Based Learning to Indiana University in 2005. McKee is active in the Team-Based Learning community and has presented internationally and nationally on the subject.
His present laboratory research focuses on understanding the mitochondrial toxicity associated with several classes of drugs. In a project funded by grants from the National Heart Lung and Blood Institute of the NIH, his laboratory studies the toxicity of anti-viral nucleoside analogs such as AZT used in the treatment of AIDS. In earlier work funded by pharmaceutical companies, McKee's group studied the toxicity of antibiotics of the oxazolidinone family as represented by the FDA approved drug linezolid (Zyvox©).
Education & Fellowships:
Department of Molecular, Cellular, and Developmental Biology
University of Colorado
N.I.H. Postdoctoral Fellowship
Department of Microbiology
University of Connecticut Health Center
The Milton S. Hershey Medical Center,
Pennsylvania State University
BS, Biochemistry, BS, Biology
Pennsylvania State University
Mitochondrial biogenesis, mitochondrial antibiotic toxicity, mitochondrial anti-cancer and antiviral nucleoside analog toxicity, deoxynucleotide metabolism, mitochondrial disease
- Alpha Zeta Professional Honorary Fraternity, 1970.
President Gerald R. Ford Feasibility Grant of the American Diabetes Association, 1984-1985.
- Sigma Xi, 1988
Recognition of merit from the American Heart Association of Metropolitan Chicago for work on Fellowship and Grant-in-Aid review committees and the Basic Science Research Counsel (1991).
- Student Research Poster entitled "Effect of potential insulin mediators on heart mitochondrial protein synthesis" (Kendra Good, and E. E. McKee) awarded first prize at Indiana State Medical Association Meeting, October, 1994
- Student Research Poster entitled "Transport of guanine nucleotides into isolated heart mitochondria." (Ronald Smith and E. E. McKee) won first prize at Indiana State Medical Association Meeting, October, 1995
- Outstanding Basic Science Professor, Indiana University School of Medicine - South Bend, Awarded by Medical School Class of 1995
- Outstanding Basic Science Professor, Indiana University School of Medicine - South Bend, Awarded by Medical School Class of 2003
Trustee Teaching Award, Indiana University School of Medicine, 2003
- Outstanding Basic Science Professor, Indiana University School of Medicine - South Bend, Awarded by Medical School Class of 2008
- Trustee Teaching Award, Indiana University School of Medicine, 2009
- Treasurer and Member of the Executive Committee, Association of Medical Biochemistry Course Directors, 2009-2012
- United Mitochondrial Disease Foundation Scientific and Medical Advisory Board 2010-present
- Vice-President and Member of the Executive Committee, Association of Medical Biochemistry Course Directors, 2011-2013 to assume President, 2013-2015
Treatment & Services:
Specialty in Diseases and Conditions:
- American Association for the Advancement of Science, 1981-present
- American Diabetes Association, Professional Section, 1984-1986
- American Society of Cell Biology, 1983-present
- American Heart Association, Basic Science Council, 1984-2003
- American Heart Association of Metropolitan Chicago, 1984-1990
- American Heart Association, Indiana Affiliate, 1992-1998
- American Society of Biochemistry and Molecular Biology, 1994-present
- Mitochondrial Research Society, 2000 – Present
- United Mitochondrial Disease Foundation, 2004-Present
- American Society of Microbiology, 2006-Present
- Team Based Learning Collaborative, 2006-Present; member of Education and Training Committee, 2010-present; treasurer and member of the Steering Committee, 2011–present.
- International Association of Medical Science Educators, 2007-Present
- Association of Medical Biochemistry Course Directors, member of executive committee, and meeting organizing committee, 2009-Present, Treasurer, 2009-2011, Vice-President, 2011-2013, assume President, 2013-2015
- United Mitochondril Disease Foundation Scientific and Medical Adviod
Basic Science of Mitochondrial Diseases
McKee has done contract research for a variety of pharmaceutical companies on potential toxicity of antibiotics to mitochondrial protein synthesis and gene expression and on the development of mitochondrial in vitro assays as high throughput drug screening systems. These studies began with Pharmacia and Upjohn (now Pfizer), Kalamazoo, MI, 1997-2002 and included Abbot Laboratories, North Chicago, Actelion Percurex AG, Basel, Switzerland, 2005-2006; Trius Therapeutics, San Diego. He has also done patent consulting on nucleoside analogs for Kenyon and Kenyon, LLC.