Dr. Justin Oh-Lee received his Ph.D. in 1995 from the University of California, Los Angeles (UCLA) in Psychology (Behavioral Neuroscience). He was a post-doctoral IRTA fellow from 1995-1999 and served as a research fellow from 1999-2001 at the Clinical Pharmacology section, Experimental Therapeutics Branch, NINDS, National Institutes of Health, Bethesda, Maryland, before coming to Central Michigan University.
Dr. Oh-Lee's principal research interests focus on the treatment of Parkinson's disease and other neurodegenerative disorders. The major goal of the laboratory is to uncover the underlying molecular, genetic, biochemical, and psychobiological abnormalities that produce clinical symptoms in neurodegenerative diseases such as Parkinson's, Alzheimer's, and Huntington's. The current emphasis is on interactions of dopamine and glutamate in regulating basal ganglia output neurons because of the relevance of these transmitters to the pathophysiology and treatment of neurodegenerative disease. Current projects include investigations of the pathogenesis of motor response complications associated with chronic levodopa therapy in Parkinson's disease.
Wang, J., Teng, Y.-H., Hao, Y., Oh-Lee, J. D.-H., & Mohanty, D. K. (2009). Preparation and properties of polyamines: Part II-Controlled and sustained release of nitric Oxide (NO) from nitrosated polymers. The Society of Polymer Science, 41(9), 715-723.
Smith, C. P. S., Oh, J. D., Bibbiani, F., Collins, M. A., Avila, I., & Chase, T. N. (2007). Tamoxifen effect on L-DOPA-induced response complications in parkinsonian rats and primates. Neuropharmacology, 52(2), 515-526.
Dunbar, G. L., Oh-Lee, J. D., & Lescaudron, L. (2006). Cell Therapy for Brain Repair; Use of bone marrow stem cells as therapy for behavioral deficits in rodent models of Huntington’s disease. In P.R Sanberg and C. Davis (Eds.), pp. 117-138, Humana Press Inc., Totowa, NJ.
Bibbiani, F., Oh J. D., Krilaite, A., Collins, M. A., Smith, C., & Chase, T. N. (2005). Combined blockade of AMPA and NMDA glutamate receptors reduces levodopa-induced motor complications in animal models of PD. Experimental Neurology, 196, 422-429.
Bibbiani, F., & Oh J. D. (2005). Motor Complications In Primate Models of Parkinson’s Disease; Animal Models of Movement Disorders (Ed: LeDoux M), pp. 209-218, Elsevier Academic Press, London, UK.