• Position: Assistant Professor
  • Department: School of Health Sciences
    Exercise and Health Sciences Division
  • Campus Address: Health Professions Building 1174
  • Phone: 989-774-2927
  • Alternate Phone: 989-774-3541
  • Email: sharm2n@cmich.edu
  • Courses: 
    HSC 503 - Health Implications of Obesity
  • Area(s) of Expertise: 
    -Exercise Physiology
  • -Insulin Resistance
    -Calorie restriction
    -Skeletal muscle
    -Cardiac muscle
    -Cell Signaling

Degrees and Universities

Bachelor of Science, Queens University (2001). Biology
Bachelor of Physical Health Education, Queens University (2001). Exercise Physiology

Masters of Science, Case Western Reserve University (2004). Exercise Physiology
Ph.D., Case Western Reserve University (2007). Nutrition
Post-Doctoral Training, University of Michigan (2010). Muscle Biology

Professional Organizations

American Neurological Society

American Association for the Advancement of Science

American Diabetes Association

American Physiological Society

American Heart Association

Endocrine Society

Michigan Physiological Society

Research Areas

Aging leads to an increased prevalence of several pathologies that are linked to insulin resistance including diabetes, cardiovascular disease, and neurological disorders.  Dr. Sharma’s lab is interested in understanding the molecular mechanisms that lead to age-associated insulin resistance, and how interventions such as diet and exercise may slow this consequence of aging.

Peer-Reviewed Publications (most recent 10 of 30)

1. Castorena CM, Arias EB, Sharma N, and Cartee GD. Effects of a brief high fat diet and acute exercise on the MTORC1 and IKK/NF-κB pathway in rat skeletal muscle. Appl Physiol Nutr Metab 40: 251-62, 2015.

2. Sharma N, Wang H, Arias EB, Castorena CM, and Cartee GD. Mechanisms for independent and combined effects of calorie restriction and acute exercise on insulin-stimulated glucose uptake by skeletal muscle of old rats. Am J Physiol Endocrinol Metab 308: E603-612, 2015.

3. Castorena CM, Arias EB, Sharma N, Bogan JS, and Cartee GD. Fiber type effects on contraction-stimulated glucose uptake and GLUT4 abundance in single fibers from rat skeletal muscle.  Am J Physiol Endocrinol Metab 308: E223-30, 2015.

4. Castorena CM, Arias EB, Sharma N, and Cartee GD. Postexercise improvement in insulin-stimulated glucose uptake occurs concomitant with greater AS160 phosphorylation in muscle from normal and insulin resistant rats.  Diabetes 63: 2297-308, 2014.

5. Sharma N, Sequea DA, Castorena CM, Arias EB, Qi NR, and Cartee GD. Heterogeneous effects of calorie restriction on in vivo glucose uptake and insulin signaling of individual rat skeletal muscles.  PLoS ONE 8e65118, doi: 10.1371/journal.pone.0065118, 2013.

6. Sequea DA, Sharma N, Arias EB, and Cartee GD. Greater filamin C serine 2213 phosphorylation in insulin-stimulated isolated skeletal muscles of calorie restricted 24 month-old rats. Mech Age Dev 134: 60-3, 2013.

7. Xiao YY, Sharma N, Arias EB, Castorena CM, and Cartee GD. A persistent increase in insulin-stimulated glucose uptake by both fast-twitch and slow-twitch skeletal muscles after a single exercise session by old rats.  Age (Dordr.) 35: 573-82, 2013.

8. Sharma N, Sequea DA, Arias EB, and Cartee GD. Greater insulin-mediated Akt phosphorylation concomitant with heterogeneous effects on phosphorylation of Akt substrates in soleus of calorie restricted rats.  Am J Physiol Regul Integr Comp Physiol.330: R1261-7, 2012.

9. Sharma N, Castorena CM, and Cartee GD. Greater insulin sensitivity and lower body fat with unaltered plasma levels of BDNF, FGF21, IL-1beta, irisin, myonectin and myostatin in calorie restricted adult ratsNutr Metab (Lond). 9: 90, 2012.

10. Sharma N, Arias EB, Sequea DA, and Cartee GD. Preventing the calorie restriction-induced increase in insulin-stimulated Akt2 phosphorylation eliminates calorie restriction's effect on glucose uptake in skeletal muscle. Biochim Biophys Acta 1822: 1735-40, 2012.