Lixin Li, PhD, MD
  • ​​​​Position: Assistant Professor
  • Department: Physician Assistant Program 
  • ​Campus Address: 1241 Health Professions Building 
  • Office Hours: By appointment 
  • Phone: (989) 774-3039
  • Email: 
  • Courses: 
    • Scientific Basis of Medicine I (PHA 633)
    • Scientific Basis of Medicine II (PHA 634)
    • Scientific Basis of Medicine III (PHA 635)
    • Clinical Medicine II (PHA 609)
    • Clinical Medicine III (PHA 610)
  • Area(s) of Expertise: Type 2 Diabetes, Insulin Resistance, Obesity, Glucagon Like Peptide- 1 (GLP-1), Atrial Natriuretic Peptide (ANP), Adipogenesis.

Degrees an​d Universities

​Dr. Lixin Li received her Medical Degree from College of Medicine, Southeast University, China and obtained her PhD degree with Dr. Valdemar Grill  from Norwegian University of Science and Technology. She completed her residency training in Internal Medicine and her fellowship training in Endocrinology in teaching hospital affiliated with Harbin Medical University, china. She passed the Canada medical licensing exam (medical council of Canada evaluating exam, medical council of Canada qualifying exam) and United States medical licensing exam. Dr. Li did her Postdoctoral training with Dr. Patricia Brubaker in the department of Physiology at University of Toronto. Her research interests have been focused on the underlying mechanism of pathogenesis of type 2 diabetes with a specific focus on β-cell dysfunction as well as the molecular mechanism of obesity associated insulin resistance. Her major research interest also include the proglucagon-derived peptides, glucagon-like peptide-1 (GLP-1) and its role in regulating growth and function of the beta-cell. Her current research is studyin gthe underlying physiological and molecular mechanisms of GLP-1 included in weight loss, and the potential role of ANP in heart-gut-far crosstalk. 

Selected Recent Publications
     Published in Peer-Reviewed Journals:

  1. ​Bashiri A, Tavallaee G, Li L, Ng D Emerging role of cellular cholesterol in the pathogenesis of nonalcoholic fatty liver disease. Curr Opin Lipidol  2013, 24:275–276

  2. Hager L, Li L*, Liu L Ng DS Lecithin: cholesterol acyltransferase deficiency protects against cholesterol-induced hepatic endoplasmic reticulum stress in mice.  J Biol Chem 2012 Jun 8; 287 (24):20755-68. (*indicates equal co-first authorship)

  3. Dong L , Kang L , Ding L, Chen Q, Bai J, Gu R, Li L, Xu B. Insulin modulates ischemia-induced endothelial progenitor cell mobilization and neovascularization in diabetic mice. Microvasc Res. 2011 Nov; 82 (3):227-36. 

  4. Li L, Tam L. Liu L, Jin T, Ng DS Wnt-signaling mediates the anti-adipogenic action of lysophophatidic acid through cross talking with the Rho/Rho associated kinase (ROCK) pathway.  Biochem Cell Biol 2011 Dec;89(6):515-21.

  5. Li L, Hossain MA, Sadat S, Hager L, Liu L, Tam L, Schroer S, Huogen,  LFantus IG, Connelly PW, Woo M, Ng DS Lecithin cholesterol acyltransferase null mice are protected from diet-induced obesity and insulin resistance in a gender-specific manner through multiple pathways. J Biol Chem. 2011 May 20; 286(20):17809-20.

  6. Li L, Naples M, Song H, Yuan R, Ye F, Shafi S, Adeli K, Ng DS LCAT-null mice develop improved hepatic insulin sensitivity through altered regulation of transcription factors and suppressors of cytokine signaling. Am J Physiol Endocrinol Metab. 2007 Aug; 293(2): E587-94

  7. Li L, Macdonald PE, Ahn DS, Oudit GY, Backx PH, Brubaker PL. Role of phosphatidylinositol 3-kinaseg (PI3-Kg) in the beta-cell: Interactions with glucagon-like peptide-1 Endocrinology 2006  Jul; 147(7): 3318-25

  8. Li L, El-Kholy W, Rhodes C, Brubaker PL.  Role of GLP-1 and PKB in prevention of cytokine–induced apoptosis in INS-1E cells Diabetologia, 2005 Jul; 48(7): 1339-49.

  9. Li Y, Cao X, Li L, Brubaker PL, Edlund H, Drucker DJ b-cell Pdx1 expression is essential for the glucoregulatory, proliferative, and cytoprotective actions of glucagon-like peptide-1 Diabetes, 2005, 54(2): 482-91

  10. Wang Q, Li L*, Xu E, Wong V, Brubaker PL Glucagon-like peptide-1 regulates proliferation and apoptosis via activation of protein kinase B in pancreatic INS-1 b-cells. (*indicates equal co-first authorship) Diabetologia, 2004, 47(3): 478-87.

  11. Li L, Yoshikawa H, Egeberg K, Grill V. Interleukin-1-b swiftly down-regulates UCP-2 mRNA in b-cells by mechanisms not directly coupled to toxicity Cy​tokine, 2003, 23(4-5): 101-7.

  12. Li L, Skorpen F, Egeberg K, Jørgensen I and Grill V. Induction of UCP-2 mRNA in beta cells is stimulated by oxidation of fatty acids but not by nutrient oversupply Endocrinology, 2002, 143(4): 1371-7

  13. Li L, Skorpen K, Egeberg K, Jørgensen I and Grill V. Uncoupling protein–2 participates in cellular defense against oxidative stress in clonal b-cells Biochemical and Biophysics Research Communications, 2001, 282: 273-277

  14. Li L, Wang W. The comparative study on CFU-F of human cord blood and normal bone marrow. Chinese Journal of Leukemia. 1997 56 :( 3): 45-53.

  15. Li L, Shi S. 2 cases of apathetic thyroid storm. Chinese Journal of Metabolism and Endocrinology, 1993, 9(2): 86-89.

  16. Li L, Shi S. The reports on the treatment of 24 cases of Diabetic Ketoacidosis with small amount of insulin by intravenous drip. HeiLongJiang Medical Journal, 1992, 94(4): 22-25
Published book chapters
  1. Li L, Lu F, Gao S, et al. The new guidance of managing diabetes, 1997, HeiLong Jiang Scientific and Technology Publication.  First edition, ISBN 7- 5388-3121-5/R.606.

Selected Published Abstracts
Oral Presentations: 

  1. Brubaker PL, Talsania T., Dube P.E. and Li L The glucagon-like peptides: pleiotropic regulators of nutrient homeostasis. Reg.Pep. 130: 137A, 2005, September, France.

  2. Li L Ahn D, Oudit G, Backx P and Brubaker P.L  Role of phosphatidylinositol 3-kinase g  (PI3-Kg) in b-cell growth: interactions with Glucagon-like peptide-1 65th American Diabetes Association (ADA) scientific sessions. 2005 June 10-14, San Diego, California. 233-OR

  3. Li L Oudit G, Backx P and Brubaker P.L The essential role of phosphatidylinositol 3-kinase (PI3-K) in GLP-1-induced b-cell growth and survival. 64h American Diabetes Association (ADA) scientific sessions.2004 June 4-8, Orlando, Florida.

  4. Li L Skorpen K, Egeberg K, Jørgensen I and Grill V Evidence that Uncoupling protein-2 participates in cellular defense against oxidative stress in b- cells.  61th American Diabetes Association (ADA) scientific sessions. Philadelphia, Pennsylvania 2001 June 22-26  206-OR

  5. Li L Skorpen K, Egeberg K, Jørgensen I and Grill V Oxidation of fatty acids in INS-1 cells is tightly coupled to expression of uncoupling protein-2.  The 36th Meeting of the Scandinavian Society for the study of Diabetes (SSSD-01), 2001 May 25-27 Uppsala, Sweden

  6. Li L Grill V Evidence that Uncoupling protein 2 regulated energy balance in clonal beta cells.  2nd Workshop of    Islet Research European Network (IREN) 2000, Geneva, Switzerland.

  7. Li L Grill V Long-term exposure of palmitate induces UCP2 gene expression in INS-1 cell line.  Satellite Conference for Research Fellows in Diabetes in Norway, 1998, , Sept. 23-25 Oslo, Norway

  8. Li L, Rhodes C, Brubaker PL  Role of GLP-1 and PKB in prevention of cytokine induced apoptosis in INS-1E cells.  64h American Diabetes Association (ADA) scientific sessions. 2004 June 4-8, Orlando, Florida. 
  9. Li L, Wang Q, Brubaker PL Glucagon-like peptide-1 regulates proliferation and apoptosis via activation of Akt1 in pancreatic (INS-1) b-cells, Banting and Best Diabetes center /Toronto Diabetes Association annual trainee awards competition 2003  (2nd place Prize winner) 

  10. Li L, Wang Q, Brubaker PL  Role for Akt1 in the stimulation of b- (INS-1) cell proliferation by glucagon-like peptide-1. 63th American Diabetes Association (ADA) scientific sessions. 2003 June 13-17  New Orleans 

  11. Li L, Grill V  Does uncoupling protein–2 participate in the regulation of energy balance in clonal beta cells? A combined islet basic science & transplantation meeting. 2000 September 21-24 Eilat, Israel

  12. Li L, Grill V Role of Uncoupling protein-2 in b-cells – evidence for regulation by energy demands of Insulin secretion. EDBC-99  1999 Oslo, Norway 

Academic membership and associations
  • American Diabetes Association
  • American Physiology Association
  • American Physician Assistant Association 

Educational activities
I am opening to accept honor student, graduate student, Postdoc fellows, and visiting scholars.