Lab members attend Fall BBQ

​​What a better way to start the 2016-2017 year than a BBQ lab? September 11 was the 2nd annual Park/Marchalant Lab party and thanks to everyone and to a pretty awesome #puremichigan weather, it was a fun outdoor one!​

Joshua Keene presents his research

Joshua Keene presented his project at the Student Research and Creative Endeavors Exhibition at CMU on April 20, 2016

Tiana Taylor presents her research at the Student Research and Creative Endeavors Exhibition.

Tiana Taylor ​presented the project she will be conducting in the lab at the Student Research and Creative Endeavors Exhibition at CMU on April 22, 2015​.


Baranger K., Marchalant Y., Bonnet A.E., Crouzin N., Carrete, A., Paumier J.M., Py N.A., Bernard A., Bauer C., Charrat E., Moschke K., Seiki, M, Vinges M., Lichtenthaler S.F., Checler F., Khrestchatisky M., Rivera S.: MT5-MMP is a new pro-amyloidogenic proteinase that promotes amyloid pathology and cognitive decline in a transgenic mous mondel of Alzheimer’s disease. Cell and Molecular Life Sciences, In press

Bonnet A.E., Marchalant Y. Potential therapeutical contributions of the endocannabinoid system towards aging and Alzheimer’s disease. Aging and Disease, (2015) 6:400-5

Py N.A., Bonnet A.E., Bernard A., Marchalant Y., Charrat E, Checler F, Khrestchatisky M, Baranger K, Rivera S. Differential spatio-temporal regulation of MMPs in the 5xFAD mouse model of Alzheimer's disease: evidence for a pro-amyloidogenic role of MT1-MMP. Front Aging Neurosci. (2014) 6:247
Marchalant Y., Brownjohn P., Bonnet A., Kleffmann T., Ashton J.: Antibody sensitivity does not imply specificity: the cannabinoid CB2 receptor. . J Histochemistry and Cytochemistry (2014) 62: 395-404

Brothers H.M., Bardou I., Hopp S.C., Marchalant Y., Kaercher R.M., Turner S.M., Mitchem M.R., Kigerl K., Wenk G.L.: Time-dependent compensatory responses to chronic neuroinflammation in hippocampus and brainstem: The potential role of glutamate neurotransmission. J Alzheimers Dis Parkinsonism (2013) 3: 110.

Crouzin N., Baranger K., Cavalier M., Marchalant Y., Cohen-Solal C., Roman F., Khrestchatisky M., Rivera S., Feron F., Vignes M. Area-specific alterations of synaptic plasticity in the 5xFAD mouse model of Alzheimer's disease: Dissociation between somatosensory cortex and hippocampus. PlosOne (2013) 8: e74667.

Bardou I., DiPatrizio N., Brothers H.M., Kaercher R.M., Baranger K., Mitchem M., Hopp S.C., WenkG.L. & Marchalant Y.: Pharmacological manipulation of cannabinoid neurotransmission reduces neuroinflammation associated with normal aging. Health (2012) 4: 679-84.

Marchalant Y., Baranger K., Wenk G.L., Khrestchatisky M., Rivera S.: Can the benefits of cannabinoid receptor stimulation on neuroinflammation, neurogenesis and memory during normal aging be useful in AD prevention? J Neuroinflammation. (2012) 9:10.

Brothers H.M, Marchalant Y., Wenk G.L.: Caffeine attenuates lipopolysaccharide-induced neuroinflammation. Neurosci Lett. (2010) 480:97-100

Marchalant Y., Brothers H.M., Wenk G.L.: Cannabinoid Agonist win-55,212-2 partially restores neurogenesis in the aged rat brain. Molecular psychiatry, (2009) 14: 1068-1071

Marchalant Y., Brothers H.M., Norman G.H., Karelina K., Devries A.C., Wenk G.L.: Cannabinoids attenuate the effects of aging upon neuroinflammation and neurogenesis. Neurobiol. Dis. (2009) 34(2): 300-307