The Field Neurosciences Institute (FNI) Laboratory is part of the Brain Research and Integrative Neuroscience (BRAIN) Center, located on the second floor of the research wing in the Health Professions Building. The research mission of the FNI laboratory is to better understand the mechanisms involved in recovery of function following damage to the central nervous system and to devise strategies to promote these mechanisms in clinically relevant ways. Current research focuses on devising potential treatments for neurodegenerative diseases, particularly Huntington’s disease (HD), Parkinson’s disease (PD), and Alzheimer’s disease (AD). >> more information
The Cognitive and Affective Neurosciences laboratory conducts research on the central and autonomic nervous system concomitants of normal and impaired psychological functioning in young adults and the elderly. Research on the cognitive and affective processing capabilities of healthy young and older adults and of adults who have neurodegenerative diseases is conducted using a battery of computerized tasks. A variety of measures are used in this laboratory, including electroencephalography (dense-array EEG and event-related brain potentials), cardiovascular (electro- and impedance cardiography, blood pressure), pulmonary, and electrodermal responses. >> more information
Bioluminescent Optogenetics Lab
A central component of activities in Ute Hochgeschwender’s laboratory is the development of technologies that use biological light, i.e. light emitted by luciferases, to activate genetically targeted light-sensing molecules, i.e. optogenetic elements. We are using a wide range of approaches and technologies, including molecular engineering, genetic engineering of model organisms, in vivo viral vector expression, in vitro multi electrode recordings, in vivo imaging, and behavioral analysis. >>more information
Engineering Psychophysiology lab
The Engineering Psychophysiology laboratory conducts research on the psychophysiology of attention in human performance. The current focus of the laboratory is on attention, distraction, and the use of advanced telematic devices during driving. A variety of central and autonomic nervous system measures are used in this laboratory, including electroencephalography (dense-array EEG and event-related brain potentials), cardiovascular (electro- and impedance cardiography, blood pressure), pulmonary, and electrodermal responses.
Neuroinflammation, Aging and Alzheimer's Lab
Dr. Yannick Marchalant's research is focused on normal and pathalogical brain aging. He is in particular looking at the influence of neuroinflammation on normal aging, on the onset of Alzheimer's disease and on ways to modulate neruoinflammatory processes to preserve normal brain functions. >>more information
Dr. Kevin Park's research interest is focused on investigating the pathological mechanisms of neurodegenerative disorders and identifying theraputic targets using animal models of amyotrophic lateral sclerosis, Huntington's disease, and Alzheimer's disease. He is currently invetstigating 1) the role of muscle transcription factors in modulating ALS disease progression; 2) the role of cdk5 and its activator p35 in HD; and 3) the role of cell-cycle activation in AD. >>more information
The Sandstrom Lab is fully equipped for neurochemistry and neurophysiology wet research preparation. Facilities are available for standard chemical preparation. Electrodes for freely-moving animal electrophysiology and iontophoresis are created with a glass electrode puller (PE-21, Narishige Japan). Tissue is preparation from animal samples is performed here. Microdialysis probes are also prepared on site for in-vivo freely-moving microdialysis from rats and mice. >> more information
The Behavior Analysis Behavioral Pharmacology Laboratory is located in rooms 201-204 of Rowe Hall. The facilities include both rodent and aviary colonies and state-of-the-art environmental control equipment and behavioral testing apparatuses. Experimental chambers are fully equipped with multiple response manipulanda and reinforcer delivery systems, including syringe pumps for drug delivery. There is a surgery room and a conference area with computer workstations for data analysis. There is also a student laboratory equipped with 10 operant conditioning stations.
Dr. Steinhilb’s research lab is equipped with resources to conduct neuroscience research including several stereo microscopes, environmental chambers designed for insect growth, molecular biology tools (PCR thermocycler, agarose/acrylamide gel electrophoresis) and tissue culture equipment. In addition, there is immediate access to the DNA Sequencing and Analysis Facility and the Microscopy Facility, both in Brooks Hall.