Gary Dunbar, Ph.D.

Gary Dunbar 

  • Position:  Faculty member in Experimental Psychology and Neuroscience Program; Director of the Neuroscience Pr​ogram and the Brain Research an​d Integrative Neuroscie​nce (BRAIN) Center; and Advisor, Central Neuroscience Society and the CMU Chapter of Nu Rho Psi, the National Honors Society for Neuroscience.
  • Department: Psychology/Neuroscience Program
  • Campus Address: Health Professions 2182, Central Michigan University, Mount Pleasant, MI 48859
  • Email: dunba1g@cmich.edu
  • Vitae: Curriculum Vitae

Website: http://www.chsbs.cmich.edu/gary_dunbar/

 

Bio:

Gary Dunbar received a B.A. in Philosophy and a B.S. in Biopsychology from Eckerd College. He received a M.A. in Psychology and a M.S. in Biology from Central Michigan University, and a Ph.D. in Psychobiology (Behavioral Neuroscience) from Clark University. He is currently the John G. Kulhavi Professor of Neuroscience and is Director of the Neuroscience Program and Brain Research and Integrative Neuroscience (BRAIN) Center. Dr. Dunbar is a member and a past President of the Faculty for Undergraduate Neuroscience and for the Michigan Chapter of the Society for Neuroscience. He was named Michigan Professor of the Year in 1997. He currently serves as the Scientific Advisor for the Michigan Chapter of the Huntington's Diseases Society of America, as Senior Editor of the Journal of Undergraduate Neuroscience Education, and as President of the American Society for Neural Therapy and Repair.

Research Interest:

Dr. Dunbar's teaching and research interests are in the area of behavioral neuroscience. His recent research is focused on the using transplants of genetically altered stem cells, dietary supplements, and pharmacological treatments for cognitive/or motor deficits following brain damage, spinal cord injury, glioblastoma, and neurodegenerative diseases, such as Huntington's, Parkinson's and Alzheimer's diseases. His research has been supported by grants and contracts from the National Institute of Health, National Science Foundation, and several pharmaceutical companies and foundations, especially the Feild Neurosciences Intstitue, for which he serves as Executive Director.

Recent Research:

(*with undergraduate, #graduate co-authors)

#Matchynski, J.J., #Lowrance, S.A.,*Pappas, C., Rossignol, J., *Puckett, N., Sandstrom, M.I., and Dunbar, G.L. (2013).A combinatorial treatment of tart cherry extract and essential fatty acids reduces cognitive impairments and inflammation in the mu-p75 saporin-induced mouse model of Alzheimer’s disease. Journal of Medicinal Food 16: 288-295.

Leveque, X., #Welchko, R., #Shall, G., #Fink, K.D., Lu, M., Rossignol, J., and Dunbar, G.L. (2013). Use of dopaminergic neurons derived from rat induced-pluripotent stem cells. Cell Transplantation 22: 908.

#Fink, K.D., Rossignol, J., #Crane, A.T., *Davis, K.K., *Bombard, M.C., *Bavar, A. M., *Clerc, S., #Lowrance, S.A., *Song, C., Lescaudron, L., and Dunbar, G.L. (2013). Transplantation of umbilical cord-derived mesenchymal stem cells into the striata of R6/2 mice: behavioral and neuropathological analysis. Stem Cell Research & Therapy 4: 130-142.

#Crane, A.T., #Fink, K.D., Rossignol, J., *Wyse, R., *Dues, D.J., *Starski, P.A., and Dunbar, G.L. (2013). Mesenchymal stem cells: source and passage number alter behavioral outcomes and life span in the R6/2 mouse model of Huntington’s disease. Cell Transplantation 22: 899.

#Fink, K.D., Rossignol, J., #Crane, A.T., #Hulse, T.D., Leveque, X., #Wyse, R., *Dues, D.J., *Huffman, L.D., *Moore, A.C., #Story, D.T., *Dejonge, R., Lu, M., Lescaudron, L., and Dunbar, G.L. (2013). Transplantation of adenovirus-generated induced pluriopotent stem cells into Huntington’s disease striatum: Analysis of survival, differentiation, and recovery of function. Cell Transplantation 22: 902.

Rossignol, J., #Fink, K.D., #Crane, A.T., *Davis, K., *Clerc, S., #Matchynski, J., #Lowrance, S., *Bombard, M., *Derkover, N., Lescaudron, L., and Dunbar, G.L. (2014). Mesenchymal and adult neural stem cell transplantations in a transgenic rat model of Huntington’s disease. Stem Cells 32: 500-509.

#Wyse, R.D., Dunbar, G.L., and Rossignol, J. (2014). Use of genetically modified stem cells to treat neurodegenerative diseases. International Journal of Molecular Science 15: 1719-1745.

Rossignol, J., #Crane, A.T., #Fink, K.D., and Dunbar, G.L. (2014) Will undifferentiated induced pluripotent stem cells ever have clinical utility? Journal of Stem Cell Research & Therapy 4: 4-7.

#Crane, A.T., Rossignol, J., and Dunbar, G.L. (2014) Use of genetically altered stem cells for the treatment of Huntington's disease. Brain Sciences, 4, 202-219.

#Fink, K.D., #Crane, T.A., Rossignol, J., Lévêque, X., *Dues, D.J., *Huffman, L.D., *Moore, A.C., #Story, D.T., *Dejonge, R.E., #Antcliff, A., #Hulse, T.D., Lu, M., Lescaudron, L., Dunbar, G.L. (2014) Intrastriatal transplantation of adenovirus-generated induced pluripotent stem cells for treating neuropathological and functional deficits in a rodent model of Huntington’s disease. Stem Cells and Translational Medicine, 3(5):620-31.

#Crane, A.T., #Fink, K.D., Grace, K.A., Grace, A.R., Antcliff, A.K., Neale, A.C., Wyse, R., Rossignol, J., and Dunbar G.L. (2014). Transplantation of adenovirus generated induced pluripotent stem cells in the 51 CAG transgenic rat model of Huntington’s disease. Cell Transplantation 23: 767-768.

Lescaudron, L., Rossignol, J., and Dunbar, G.L. Stem Cells and Neurodegenerative Diseases. CRC Press, Taylor & Francis Group, Science Publishers, Enfield, New Hampshire, 2014.

#Fink, K.D., #Crane, A.T., Rossignol, J., Lescaudron, L., and Dunbar, G.L. The use of stem cells in treating Huntington's disease: state of research and prospects for future treatments. In Lescaudron, L., Rossignol, J., and Dunbar, G.L. (Eds.), Stem Cells and Neurodegenerative Diseases, CRC Press, Taylor & Francis Group,Science Publishers, Enfield, New Hampshire, pp 20-55.

#Lowrance, S.A., #Fink, K.D., #Crane, A., #Matyas, J., #Dey, N.D., *Thibo, T., *Reinke, T., *Kippe, J., *Hoffman, C., Sandstrom, M., Rossignol, J., and Dunbar, G.L. (2014). Bone marrow derived mesenchymal stem cells attenuate cognitive deficits in an enothelin-1 rat model of stroke. Restorative Neurology and Neuroscience (in press).

#Fink, K.D., Rossignol, J., Lu, M., Leveque, X., #Hulse, T.D., #Crane, A.T., Nerriere-Daguin, V., #Wyse, R.D., *Starski, P.A., *Schloop, M.T., *Dues, D.J., *Witte, S. J., *Song, C., Vallier, L. , Nguyen, T. H., Naveilhan, P. Andgon, I., Lescaudron, L., and Dunbar, G. L. (2014). Survival and differentiation of adenovirus-generated induced pluripotent stem cells transplanted into the rat striatum. Cell Transplantation (in press).