Neuroinflammation, Aging and Alzheimer's Lab
Dr. Yannick Marchalant obtained his Ph.D. from the University of Caen, France in 2004. After graduating, he moved to the University of Arizona and then onto The Ohio State University as a post-doctoral researcher for 4 years. He then became a research assistant professor in 2008 at The Ohio State University for 2 years. He moved back to Europe for 4 years in Aix-Marseille University, France and joined the Psychology Department at Central Michigan University in the fall of 2014 as an assistant professor. He has been working for 15 years on neurodegenerative disease, in particular Alzheimer's disease, and has studied notably the role of neuroinflammation in brain aging as well as the influence of the endocannabinoid system on the regulation of inflammatory processes in the context of Alzheimer's disease.
For the last 20 years, I have been working on different aspects of normal and pathological aging (behavioral to molecular approaches), notably Alzheimer's disease.
More recently I have been more focus on the role of inflammatory processes in the development of Alzheimer's disease and trying to identify ways to target them.
We are currently actively looking at:
- The role of early inflammation (pre-symptomatic) in the 5xFAD mouse model of Alzheimer's disease.
- The role of early systemic chronic inflammation in the regulation of amyloid plaques formation and neuronal structure in the NL-G-F knock-in mouse model of Alzheimer's disease.
We are hoping that those projects will lead to a better understanding of the contribution of inflammatory processes in the neurodegenerative context that is Alzheimer's disease.
Baranger K., Marchalant Y., Bonnet A.E., Crouzin N., Carrete, A., Paumier J.M., Py N.A., Bernard A., Bauer C., Charrat E., Moschke K., Seiki, M, Vinges M., Lichtenthaler S.F., Checler F., Khrestchatisky M., Rivera S.: MT5-MMP is a new pro-amyloidogenic proteinase that promotes amyloid pathology and cognitive decline in a transgenic mous mondel of Alzheimer's disease. Cell and Molecular Life Sciences (2016) 1:217-236
Bonnet A.E., Marchalant Y. Potential therapeutical contributions of the endocannabinoid system towards aging and Alzheimer's disease. Aging and Disease, (2015) 6:400-5
Py N.A., Bonnet A.E., Bernard A., Marchalant Y., Charrat E, Checler F, Khrestchatisky M, Baranger K, Rivera S. Differential spatio-temporal regulation of MMPs in the 5xFAD mouse model of Alzheimer's disease: evidence for a pro-amyloidogenic role of MT1-MMP. Front Aging Neurosci. (2014) 6:247
Marchalant Y., Brownjohn P., Bonnet A., Kleffmann T., Ashton J.:
Antibody sensitivity does not imply specificity: the cannabinoid CB2 receptor.
. J Histochemistry and Cytochemistry (2014) 62: 395-404
H.M., Bardou I., Hopp S.C.,
Marchalant Y., Kaercher R.M., Turner S.M., Mitchem M.R., Kigerl K., Wenk
Time-dependent compensatory responses to chronic neuroinflammation in hippocampus and brainstem: The potential role of glutamate neurotransmission.
J Alzheimers Dis Parkinsonism
(2013) 3: 110.
C., Roman F., Khrestchatisky
Area-specific alterations of synaptic plasticity in the 5xFAD mouse model of Alzheimer's disease: Dissociation between somatosensory cortex and hippocampus
(2013) 8: e74667.
Bardou I., DiPatrizio N., Brothers
H.M., Kaercher R.M., Baranger
K., Mitchem M., Hopp S.C., Wenk
Pharmacological manipulation of cannabinoid neurotransmission reduces neuroinflammation associated with normal aging.
(2012) 4: 679-84.
Marchalant Y., Baranger K., Wenk G.L., Khrestchatisky M., Rivera S.: Can the benefits of cannabinoid receptor stimulation on neuroinflammation, neurogenesis and memory during normal aging be useful in AD prevention?
J Neuroinflammation. (2012) 9:10.
Marchalant Y., Wenk G.L.: Caffeine attenuates lipopolysaccharide-induced neuroinflammation.
Neurosci Lett. (2010) 480:97-100
Brothers H.M., Wenk G.L.: Cannabinoid Agonist win-55,212-2 partially restores neurogenesis in the aged rat brain.
Molecular psychiatry, (2009) 14: 1068-1071
Brothers H.M., Norman G.H., Karelina K., Devries A.C., Wenk G.L.: Cannabinoids attenuate the effects of aging upon neuroinflammation and neurogenesis.
Neurobiol. Dis. (2009) 34(2): 300-307