Website: Neuroinflammation, Aging and Alzheimer's Lab

Bio:

Dr. Yannick Marchalant obtained his Ph.D. from the University of Caen, France in 2004. After graduating, he moved to the University of Arizona and then onto The Ohio State University as a post-doctoral researcher for 4 years. He then became a research assistant professor in 2008 at The Ohio State University for 2 years. He moved back to Europe for 4 years in Aix-Marseille University, France and joined​ the Psychology Department at Central Michigan University in the fall of 2014 as an assistant professor. He has been working for 15 years on neurodegenerative disease, in particular Alz​heimer's disease, and has studied notably the role of neuroinflammation in brain aging as well as the influence of the endocannabinoid system on the regulation of inflammatory processes in the context of Alzheimer's disease.

Research Interest:

For the last 20 years, I have been working on different aspects of normal and pathological aging (behavioral to molecular approaches), notably Alzheimer's disease.

More recently I have been more focus on the role of inflammatory processes in the development of Alzheimer's disease and trying to identify ways to target them.

Ongoing projects:

  • Using the 5xFAd mouse model of AD, we are exploring the role of priming in microglia cells in pre-symptomatic phase of Alzheimer's disease
  • Using a mouse model developed by CMU's colleague Dr Kevin Park, and in collaboration with Dr Dave Morgan at MSU, we are studying the role of systemic inflammation on Alzheimer's disease progression
  • Using aged rats and in collaboration with Dr Naveen Sharma at CMU, we are studying the influence of Krill Oil supplementation, with or without high fat diets, on cognitive and inflammatory processes

We have and are continuously happy to contribute to undergraduate student's research experience at CMU. If you are interested in learning more about the lab or joining, please contact Dr Marchalant (march1y@cmich.edu) for more details.

Recent Research:

  • Andraka J., Sharma N., Marchalant Y.: Can Krill oil be use for counteracting neuroinflammatory processes induced by high fat diet and aging? Neuroscience Research, 2019 doi: 10.1016/j.neures.2019.08.001
  • Barrett T., Marchalant Y., Park K.H.: p35 hemizygous deletion in 5xFAD mice increases Aβ plaque load in males but not in females. Neuroscience, 2019 doi: 10.1016/j.neuroscience.2019.08.017
  • Baranger K., Marchalant Y., Bonnet A.E., Crouzin N., Carrete, A., Paumier J.M., Py N.A., Bernard A., Bauer C., Charrat E., Moschke K., Seiki, M, Vinges M., Lichtenthaler S.F., Checler F., Khrestchatisky M., Rivera S.: MT5-MMP is a new pro-amyloidogenic proteinase that promotes amyloid pathology and cognitive decline in a transgenic mous mondel of Alzheimer's disease. Cell and Molecular Life Sciences (2016) 1:217-236
  • Bonnet A.E., Marchalant Y. Potential therapeutical contributions of the endocannabinoid system towards aging and Alzheimer's disease. Aging and Disease, (2015) 6:400-5
  • Py N.A., Bonnet A.E., Bernard A., Marchalant Y., Charrat E, Checler F, Khrestchatisky M, Baranger K, Rivera S. Differential spatio-temporal regulation of MMPs in the 5xFAD mouse model of Alzheimer's disease: evidence for a pro-amyloidogenic role of MT1-MMP. Front Aging Neurosci. (2014) 6:247
  • Marchalant Y., Brownjohn P., Bonnet A., Kleffmann T., Ashton J.: Antibody sensitivity does not imply specificity: the cannabinoid CB2 receptor. . J Histochemistry and Cytochemistry (2014) 62: 395-404