Dr. Stephen Juris 
Dr. Juris

About Dr. Stephen Juris

Job Title: Associate Professor of Biology

Dr. Juris’ research interests are focused on the biochemical and cell biological action of bacterial toxins that target the actin cytoskeleton.

Pathogenic bacteria often secrete toxins that target the cytoskeleton in order to subvert the immune defenses of their host. These toxins must gain access to the cytosol of target cells via transport across a biological membrane in order to carry out their function. Once inside the target cell, these bacterial toxins carry out a multitude of different activities including proteolysis, phosphorylation, or other post-translational modification of host proteins in order to down-regulate signaling cascades connected with the actin cytoskeleton in order to inhibit innate immune processes including phagocytosis and chemotaxis.

His goals are to understand the transport of the actin-targeting toxin RTX from Vibrio cholerae across cellular membranes and its subsequent action on the actin cytoskeleton within target cells. The Juris lab utilizes biochemistry, cell biology, biophysics and genetics to study these questions.

Contact Dr. Juris at juris1sj@cmich.edu, or visit him in his office in Dow 338.