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Mallary Wacker

Photo of Elizabeth W. AlmAssistant Professor
Immunology, Imflammation, Host-Pathogen Interactions, and S. aureus
Biology​ 

Biosciences 4107
989-774-1143
wacke1m@cmich.edu

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Education​​
  • Postdoctoral Researcher, University of Iowa, 2011-2016
  • Ph.D., University of Notre Dame, 2011
  • B.S., University of California, Irvine, 2006
​​​Research Interests
Immunology, inflammation, interferon-gamma, host-pathogen interactions, and S. aureus

​​​Current Research Projects
​My research is aimed at understanding how the bacterium Staphylococcus aureus perturbs the ability of human phagocytes to effectively kill ingested bacteria and regulate excessive inflammation.  Phagocytosis is the ingestion of particles greater than 0.5 microns. Phagocytes, including neutrophils, monocytes, and macrophages, are critical both for host-defense and resolution of acute inflammation.  Although inflammation is a normal physiological process meant to deal with pathogens and stress, excessive inflammation can be destructive. Understanding how S. aureus manipulates phagocytes will provide insights into the pathogenesis of staphylococcal infections.  
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​​​​Selected Publications
  • Greenlee-Wacker, M.C., Kremserová, S. and Nauseef, W.M. Lysis of human neutrophils by community-associated methicillin-resistant Staphylococcus aureus is independent of RIPK-1. Blood.  2017. 129(24):3237-3244.
  • Greenlee-Wacker, M.C., Nauseef, W.M. IFN-γ targets macrophage-mediated immune responses towards Staphylococcus aureus. Journal of Leukocyte Biology. 2017. 101(3):751-758.
  • Greenlee-Wacker, M.C. Clearance of apoptotic neutrophils and resolution of inflammation. Immunological Reviews. 2016.  273(1):357-70.
  • Greenlee-Wacker, M.C. DeLeo F.R. and Nauseef, W.M. How methicillin-resistant S. aureus evade neutrophil killing. Current Opinion in Hematology. 2015. 22(1):30-35.
  • Greenlee-Wacker, M.C., Rigby, K.M., Kobayashi, S.D., Porter, A.R., DeLeo, F.R., and Nauseef, W.M. Phagocytosis of Staphylococcus aureus by human neutrophils prevents macrophage efferocytosis and induces programmed necrosis.  Journal of Immunology. 2014, 192(10), 4709-17.
  • Greenlee-Wacker, M.C., Briseño, C., Galvan, M., Morel, G., Velázquez, P., and Bohlson, SS.  CD93 regulates inflammation during murine peritonitis.  Journal of Immunology.  2011, 187(6):3353-61.
  • Kozmar, A., Greenlee-Wacker, M.C., Bohlson, S.S.  Macrophage response to apoptotic cells varies with the apoptotic trigger and is not altered by a deficiency in LRP expression.  Journal of Innate Immunity.  2010, 2(3):248-59.