|My lab investigates the biological problem of cellular stress using the model organism, Saccharomyces cerevisiae, also known as budding yeast. Using cell biology, genetic, molecular biology, and microscopy techniques we investigate the following:
- How oxidative stress and mitochondrial morphology influences spore viability and fitness,
- Understanding how fermentation inhibitors affect the basic biology of yeast in order to engineer robust yeast strains.
- How oxidative stress is linked to mitochondrial based diseases.
Nichols, N.N., M.P. Szynkarek, C.D. Skory, S.W. Gorsich, M.J. Lopez, G.M. Guisado, W.A. Nichols. 2011. Transformation and electrophoretic karyotyping of Coniochaeta ligniaria NRRL30616. Curr. Genet. 57:169-75.
- Allen, S*, W. Clark*, J.M. McCaffery, Z. Cai*, A. Lanctot*, P.J. Slininger, Z.L. Liu, S.W. Gorsich. 2010. Furfural induces reactive oxygen species accumulation and cellular damage in Saccharomyces cerevisiae. Biotechnol. Biofuels. 3:2.
- Almeida, J.R., M. Bertilsson, M-F. Gorwa-Grauslund, S. Gorsich, G. Liden. 2009. Metabolic effects of furaldehydes and impacts on biotechnological processes. Appl. Microbiol. Biotechnol. 82: 625-38 (Review).
- Slininger, P.J., S.W. Gorsich, Z.L. Liu. 2008. Culture nutrition and physiology impact the inhibitor tolerance of the yeast Pichia stipitis NRRL Y-7124. Biotechnol. Bioengineer. 102: 778-90.
Gorsich, S.W., B.S. Dien, N.N. Nichols, P.J. Slininger, Z.L. Liu, C. Skory. 2006. Tolerance to furfural-induced stress is associated with pentose phosphate pathway genes ZWF1, GND1, RPE1, and TKL1 in Saccharomycescerevisiae. Appl. Microbiol. Biotechnol. 71: 339-349.
Gorsich, S.W. J.M. Shaw. 2004. Importance of mitochondrial dynamics during meiosis and sporulation. Mol. Biol. Cell 15: 4369-81.