Research Lab 116
Central Michigan University
Mount Pleasant, MI 48859
D. Stave Kohtz, Ph.D., received his BA in Biochemistry from Columbia University in New York, and his Ph.D. in Molecular and Cellular Pathology from Mount Sinai School of Medicine (now Icahn). His thesis included discovery of AP180/NP185/AP-3, a neuronal protein critical to endocytic and synaptic vesicle function. He joined the Department of Pathology at Mount Sinai immediately after receiving his Ph.D., eventually achieving the rank of Associate Professor. At Mount Sinai Dr. Kohtz served as Principal Investigator on several federal and foundation-funded research projects, and mentored students and fellows at all levels. He also facilitated implementation and development of case-based small group learning systems.
Early studies from the Kohtz laboratory include widely cited results on regulation of cell cycle progression and differentiation in cardiac and skeletal muscle systems. The Kohtz laboratory pioneered studies showing the importance of protein chaperones in control of transcription factor activity, and collaborated to first identify caveolin-2, a protein involved in certain types of muscular dystrophy. The laboratory reported seminal studies on axon guidance signaling in the pathogenesis of Alzheimer's and Parkinson's disease. More recently, the laboratory has reported a role for nuclear pore architecture in cells responding to different stressors, including cancer cells responding to chemotherapy and hippocampal neurons responding to psychosocial stress.
Dr. Kohtz joined CMU College of Medicine in spring 2016 as Professor of Pathology in Foundational Sciences. His laboratory is working to understand how changes in nuclear pore architecture, induced by factors such as psychosocial stress, affect therapeutic responses in cancer patients.
- Graduate School: Ph.D. Mont Sinai School of Medicine