For the last 20 years, I have been working on different aspects of normal and pathological aging (behavioral to molecular approaches), notably Alzheimer’s disease.

More recently I have been more focus on the role of inflammatory processes in the development of Alzheimer’s disease and trying to identify ways to target them.

Ongoing projects:

  • Using the 5xFAd mouse model of AD, we are exploring the role of priming in microglia cells in pre-symptomatic phase of Alzheimer’s disease
  • Using a mouse model developed by CMU’s colleague Dr Kevin Park, and in collaboration with Dr Dave Morgan at MSU, we are studying the role of systemic inflammation on Alzheimer’s disease progression
  • Using aged rats and in collaboration with Dr Naveen Sharma at CMU, we are studying the influence of Krill Oil supplementation, with or without high fat diets, on cognitive and inflammatory processes

We have and are continuously happy to contribute to undergraduate student’s research experience at CMU. If you are interested in learning more about the lab or joining, please contact Dr Marchalant (march1y@cmich.edu) for more details.