The FLO-SIC Center is one of several new Computational Chemical Sciences Centers funded by the U.S. Department of Energy in September, 2017. Central Michigan University (CMU) is the lead institution in FLO-SIC, joined by research teams from Temple University, the University of Texas-El Paso, the University of Florida, and the University of Pittsburgh. The Center’s research is aimed at developing improved first-principles methods for computationally modeling molecules and materials at the atomic level. The ultimate goal of the Center is to produce open source software that allows efficient and predictive modeling of materials without unphysical effects of electron self-interaction, the major flaw present in existing methods.