The use of select carcinogens, reproductive toxins, and substances that have a high degree of acute or chronic toxicity REQUIRES
a written standard operating procedure. The procedure must include the
establishment of a designated area with appropriate signs warning of
the hazards associated with the substance, the use of a fume hood or
equivalent containment device, procedures for decontaminating the
designated area, and procedures for safe removal of contaminated waste.
PROCEDURE TEMPLATE (to be filled out and kept in each lab)
Particularly hazardous substances, by MIOSHA definition, are select carcinogens, reproductive toxins and chemicals with a high degree of acute and chronic toxicity. Select carcinogens
are chemicals listed by MIOSHA as carcinogens, by the National
Toxicology Program (NTP) as “known to be carcinogens” and by the
International Agency for Research on Cancer (IARC) as Group 1
carcinogens. Also included are chemicals or processes listed in either
Group 2A or 2B by IARC or under the category “reasonably anticipated to
be carcinogens” by NTP and that cause statistically significant tumor
incidence in experimental animals in accordance with any of the
inhalation exposure of 6-7 hours per day, 5 days per week, for a
significant portion of a lifetime to dosages of less than 10 mg/m 3
- After repeated skin application of less than 300 mg/kg of body weight per week.
- After oral dosages of less than 50 mg/kg of body weight per day
Reproductive toxins are defined
by MIOSHA as any chemical which affects the reproductive capabilities of
males or females, including chromosomal damage (mutagenesis) and
effects on fetuses (teratogenesis). Information on reproductive effects
will be listed on the MSDS.
Chemicals with a high degree of acute and chronic toxicity
are not defined in the Laboratory Standard. Therefore, the MIOSHA
Hazard Communication definition of a highly toxic chemical will be
used. Chemicals with a high degree of acute toxicity are chemicals that
have a median lethal dose (LD 50) of 50 milligrams or less
per kilogram of body weight when administered orally to albino rats
weighing between 200 and 300 grams each. The LD 50 is that
dose at which a lethal response is observed in 50% of the test animals.
The hazard(s) of a chemical may also be listed on its container label.
Additionally, if the hazard of a chemical is not evident from the
container label, the MSDS will list the specific hazards. Use the MSDS
to address chronic toxicity.
For further help in determining the hazard of a chemical, contact your supervisor or the Safety Coordinator.
2. Designated areas
Work with these categories of chemicals must be
conducted in a designated area. Designated areas may include a hood,
glove box, portion of a laboratory, or entire laboratory room. Post
signs on designated areas and clearly mark/define the boundaries.
3. Guidelines/procedures for employees working in designated areas
- Be trained to work with these highly toxic chemicals.
- Use the smallest amount of chemical that is practical.
- Use high-efficiency particulate air (HEPA) filters or high-efficiency scrubber systems to protect vacuum lines and pumps.
- Decontaminate a designated area when work is completed.
wastes in accordance with the Resource Conservation and Recovery Act
(RCRA) and as designated by the University Hazardous Waste Manager.
- Store these chemicals in locked and enclosed spaces with a slight negative pressure compared to the room.
- Not wear jewelry in designated areas.
- Wear eye protection and long-sleeved disposable clothing and gloves known to resist permeation by the chemicals to be used.