Rossignol Research

Julien Rossignol's lab is part of the Field Neurosciences Institute Laboratory for Restorative Neurology that he co-directs with Gary L. Dunbar, Ph.D.

Dr. Rossignol (seated right), with collaborators Dr. Dunbar (rear right), Dr. Sharma (rear left) and grad student (seated left) work together on an interdisciplinary project researching Huntington’s disease.The Field Neurosciences Institute (FNI) Laboratory for Restorative Neurology is part of the Brain Research and Integrative Neuroscience (BRAIN) Center, located on the second floor of the research wing in the Herbert H. and Grace A. Dow College of Health Professions building. The research mission of the FNI Laboratory is to better understand the mechanisms involved in the recovery of function following damage to the central nervous system and to devise strategies to promote these mechanisms in clinically relevant ways. Current research focuses on dendrimer nanomolecule-based delivery of genes and drug delivery devising potential treatments for neurodegenerative diseases, particularly Huntington’s disease (HD), Parkinson’s disease (PD), and Alzheimer’s disease (AD), stroke, and brain tumors such as glioblastoma multiforme (GB).

PAMAM dendrimer nanomolecules

We use an in-house PAMAM dendrimer nanomolecules with mixed-surface synthesized by our collaborators, Ajit Sharma, Ph.D., and Douglas Swanson, Ph.D., from the Department of Chemistry and Biochemistry. These dendrimers are non-toxic to cells in vitro and in vivo and have the ability to carry large amounts of cargo (drugs and genes/biomolecules). The surface modification that we have done to the conventional amine surface dendrimers enables our dendrimers to be less toxic and yet be uptaken by the cells. We have also shown that these modified dendrimer nanomolecules can cross the blood-brain barrier following their systemic injections into the arteries and veins in mice.

A graphic depiction of surface modified PAMAM dendrimer nanomolecules.

Student volunteers

We are currently looking for student volunteers who would like to gain valuable laboratory experience and those who would like to complete an honors capstone project and are interested in our ongoing neuroscience research.

Contact Dr. Rossignol