In 1997, the College of Health Professions was established in conjunction with a university-wide reorganization of Academic Units. It consisted of two departments, the Department of Communication Disorders and the Department of Health Promotion and Rehabilitation.

Stephen Kopp, Ph.D., was the founding Dean of the college and served from 1997 to 2002. Under Dr. Kopp'sOutside of the College of Health Professions leadership, a new Health Professions Building was planned and initiated. 

In 1998, the Department of Physical Education and Sport joined the college. In 1999, the Health Professions Residential College was officially opened. 

In 2000, The College of Health Professions was officially named "The Herbert H. and Grace A. Dow College of Health Professions." In that same year an interdisciplinary clinic wing in the soon to be built Health Professions Building was created, named "The Carls Center for Clinical Care and Education." In 2001, the Health Professions Building Ground Breaking occurred. 

In 2002, the School of Rehabilitation and Medical Sciences was created to house the Physical Therapy and Physician Assistant Programs. The Department of Health Promotion and Rehabilitation was renamed to the School of Health Sciences which houses the Divisions of Community Health, Exercise Science, and Health Administration. 

Marvis Lary, Ph.D., was chosen as the second Dean of the College and served from 2002 to 2007. In January 2004, the Health Professions Building opened for classes. During these years the college programs grew significantly to the point that the Health Professions Building was full. 

Thomas Masterson, Jr., Ph.D. served as interim Dean from September 2007 through May 2009 while a search for the next dean took place. 

Health Professions AtriumChristopher Ingersoll, Ph.D., was named Dean in June 2009 and served until January 2015. During Dr. Ingersoll's years, a significant number of research active faculty were hired and Health Administration was relocated to Rowe Hall and Sport Management to Foust Hall. 

Thomas Masterson, Jr., Ph.D., was named Interim Dean in January 2015 and continues to serve as Dean after a national search was conducted in 2016. In June 2016, funding was approved by the State of Michigan for the addition to the Health Professions building known as the Center for Integrated Health Studies. The addition is designed to promote interdisciplinary education among all CMU clinical programs. 

Today in 2018, the College has programs in four different buildings on campus (Health Professions, Foust Hall, Rowe Hall, and the SAC).