Mckee, Edward
Ph.D.
Biography
Ed McKee, Ph.D., is a biochemist specializing in mitochondrial metabolism and biogenesis and is an expert in the pedagogy of Team-Based-Learning. He joined Central Michigan University College of Medicine in 2011 as the chair of Foundational Sciences and professor of Biochemistry and Medical Genetics. He was appointed interim senior associate dean of Research, Administration and Faculty Affairs in 2014 and senior associate dean of Research from 2016-2021 He is now serving as professor with tenure of Biochemistry and Medical Genetics. McKee teaches biochemistry and genetics throughout the curriculum and has served as co-course director of the Gastrointestinal Course. He is now the course operations manager of the Cellular and Molecular Principles of Medicine course. Edward McKee received B. S. degrees in biology and biochemistry from Pennsylvania State University in University Park, PA. He received his Ph. D. degree in physiology from the M. S. Hershey Medical Center, College of Medicine, Penn State University. His graduate work involved studies on the regulation of protein metabolism in the perfused rat heart. Following post-doctoral fellowships in the Department of Microbiology at the University of Connecticut Health Science Center in Farmington, Connecticut and in the Department of Molecular, Cellular and Developmental Biology at the University of Colorado in Boulder. McKee took a faculty position in the Department of Biochemistry at what is now the Rosalind Franklin University of Health Science / The Chicago Medical School. McKee served on the faculty of the Indiana University School of Medicine at the University of Notre Dame Branch from 1991-2011. McKee is active in the Team-Based Learning community and has given workshops on Team-Based learning at National and International meetings as well as at universities and medical schools. He has served as treasurer and a member of the executive committee of the Team Based Learning Collaborative. McKee also served as ice-president of the Association of Biochemistry Educators (ABE), a group dedicated to supporting and enhancing the teaching of biochemistry in medical, dental and pharmacy schools. His past laboratory research was on understanding the mitochondrial toxicity associated with several important classes of drugs. In a project funded by grants from the National Heart Lung and Blood Institute of the NIH. McKee’s laboratory studies the toxicity of anti-viral nucleoside analogs such as AZT used in the treatment of AIDS. In earlier work funded by pharmaceutical companies, McKee’s group studied the toxicity of antibiotics of the oxazolidinone family as represented by the FDA approved drug linezolid (Zyvox©). In current work, Dr.McKee is studying several mitochondrial DNA depletion diseases using rat models of the diseases.
More about Edward Mckee
Publications & Presentations
Snowdin JW, Hsiung CH, Kesterson DG, Kamath VG, McKee EE (2015). Effects of Zidovudine Treatment on Heart mRNA Expression and Mitochondrial DNA Copy Number Associated with Alterations in Deoxynucleoside Triphosphate Composition in a Neonatal Rat Model. Antimicrobial agents and chemotherapy.
Kamath VG, Hsiung CH, Lizenby ZJ, McKee EE (2015). Heart mitochondrial TTP synthesis and the compartmentalization of TMP. The Journal of biological chemistry.
Flanagan S, McKee EE, Das D, Tulkens PM, Hosako H, Fiedler-Kelly J, Passarell J, Radovsky A, Prokocimer P (2015). Nonclinical and pharmacokinetic assessments to evaluate the potential of tedizolid and linezolid to affect mitochondrial function. Antimicrobial agents and chemotherapy.
Xi J, Si XA, Kim J, Mckee E, Lin EB (2014). Exhaled aerosol pattern discloses lung structural abnormality: a sensitivity study using computational modeling and fractal analysis. PloS one.
McCann KA, Williams DW, McKee EE (2012). Metabolism of deoxypyrimidines and deoxypyrimidine antiviral analogs in isolated brain mitochondria. Journal of neurochemistry.
Edward E. McKee, Selma Omer (2011). Applying Thermodynamics, Enzyme Kinetics, and pH in Medical Biochemistry - a Team-Based Learning Exercise MedEdPortal.
Edward E. McKee (2011). Team Based Learning Exercise Risk Analysis in Genetics MedEdPortal.
Edward E. McKee, Selma Omer (2011). Protein Structure in Medicine A Team-Based Learning Exercise MedEdPortal.
Edward E. McKee, George W. Knowles, W. Marshall Andersen (2010). Team-Based Learning Exercise -Nutrition and Metabolism: The Hunger Strike MedEdPortal.
Olivero OA, Vazquez IL, Cooch CC, Ming J, Keller E, Yu M, Borojerdi JP, Braun HM, McKee E, Poirier MC (2010). Long-term AZT exposure alters the metabolic capacity of cultured human lymphoblastoid cells. Toxicological sciences : an official journal of the Society of Toxicology.
Morris GW, Laclair DD, McKee EE (2010). Pyrimidine deoxynucleoside and nucleoside reverse transcriptase inhibitor metabolism in the perfused heart and isolated mitochondria. Antiviral therapy.
McHenry P, Wang WL, Devitt E, Kluesner N, Davisson VJ, McKee E, Schweitzer D, Helquist P, Tenniswood M (2010). Iejimalides A and B inhibit lysosomal vacuolar H+-ATPase (V-ATPase) activity and induce S-phase arrest and apoptosis in MCF-7 cells. Journal of cellular biochemistry.
Lynx MD, LaClair DD, McKee EE (2009). Effects of zidovudine and stavudine on mitochondrial DNA of differentiating 3T3-F442a cells are not associated with imbalanced deoxynucleotide pools. Antimicrobial agents and chemotherapy.
Morris GW, Iams TA, Slepchenko KG, McKee EE (2009). Origin of pyrimidine deoxyribonucleotide pools in perfused rat heart: implications for 3'-azido-3'-deoxythymidine-dependent cardiotoxicity. The Biochemical journal.
Lynx MD, Kang BK, McKee EE (2008). Effect of AZT on thymidine phosphorylation in cultured H9c2, U-937, and Raji cell lines. Biochemical pharmacology.
Donnino MW, Miller J, Garcia AJ, McKee E, Walsh M (2007). Distinctive acid-base pattern in Wernicke's encephalopathy. Annals of emergency medicine.
Susan-Resiga D, Bentley AT, Lynx MD, LaClair DD, McKee EE (2007). Zidovudine inhibits thymidine phosphorylation in the isolated perfused rat heart. Antimicrobial agents and chemotherapy.
Madariaga MG, Swindells S, McKee EE (2007). Oxazolidinones and human immunodeficiency virus. Antimicrobial agents and chemotherapy.
Lynx MD, McKee EE (2006). 3'-Azido-3'-deoxythymidine (AZT) is a competitive inhibitor of thymidine phosphorylation in isolated rat heart and liver mitochondria. Biochemical pharmacology.
Lynx MD, Bentley AT, McKee EE (2006). 3'-Azido-3'-deoxythymidine (AZT) inhibits thymidine phosphorylation in isolated rat liver mitochondria: a possible mechanism of AZT hepatotoxicity. Biochemical pharmacology.
McKee EE, Ferguson M, Bentley AT, Marks TA (2006). Inhibition of mammalian mitochondrial protein synthesis by oxazolidinones. Antimicrobial agents and chemotherapy.
McKee EE, Bentley AT, Hatch M, Gingerich J, Susan-Resiga D (2004). Phosphorylation of thymidine and AZT in heart mitochondria: elucidation of a novel mechanism of AZT cardiotoxicity. Cardiovascular toxicology.
McKee EE, Bentley AT, Smith RM Jr, Kraas JR, Ciaccio CE (2000). Guanine nucleotide transport by atractyloside-sensitive and -insensitive carriers in isolated heart mitochondria. American journal of physiology. Cell physiology.
McKee EE, Bentley AT, Smith RM Jr, Ciaccio CE (1999). Origin of guanine nucleotides in isolated heart mitochondria. Biochemical and biophysical research communications.
Poyton RO, Bellus G, McKee EE, Sevarino KA, Goehring B (1996). In organello mitochondrial protein and RNA synthesis systems from Saccharomyces cerevisiae. Methods in enzymology.
McKee EE (1994). Mitochondrial gene expression in Saccharomyces cerevisiae. IV. Effects of yeast cytosol on mitochondrial protein synthesis, degradation, and respiration. Biochimica et biophysica acta.
Czerwinski SM, Kurowski TT, McKee EE, Zak R, Hickson RC (1991). Myosin heavy chain turnover during cardiac mass changes by glucocorticoids. Journal of applied physiology (Bethesda, Md. : 1985).
Black-Schaefer CL, McCourt JD, Poyton RO, McKee EE (1991). Mitochondrial gene expression in Saccharomyces cerevisiae. Proteolysis of nascent chains in isolated yeast mitochondria optimized for protein synthesis. The Biochemical journal.
McKee EE, Grier BL (1990). Insulin stimulates mitochondrial protein synthesis and respiration in isolated perfused rat heart. The American journal of physiology.
Leung AC, McKee EE (1990). Mitochondrial protein synthesis during thyroxine-induced cardiac hypertrophy. The American journal of physiology.
McKee EE, Grier BL, Thompson GS, Leung AC, McCourt JD (1990). Coupling of mitochondrial metabolism and protein synthesis in heart mitochondria. The American journal of physiology.
McKee EE, Grier BL, Thompson GS, McCourt JD (1990). Isolation and incubation conditions to study heart mitochondrial protein synthesis. The American journal of physiology.
Czerwinski SM, McKee EE, Hickson RC (1989). Glucocorticoid receptor activation in isolated perfused rat hearts. The American journal of physiology.
McKee EE, Poyton RO (1984). Mitochondrial gene expression in saccharomyces cerevisiae. I. Optimal conditions for protein synthesis in isolated mitochondria. The Journal of biological chemistry.
McKee EE, McEwen JE, Poyton RO (1984). Mitochondrial gene expression in saccharomyces cerevisiae. II. Fidelity of translation in isolated mitochondria from wild type and respiratory-deficient mutant cells. The Journal of biological chemistry.
Beinlich CJ, Clark MG, McKee EE, Lins JA, Morgan HE (1981). Neutral-alkaline proteolytic activity in rat cardiac muscle cells. Journal of molecular and cellular cardiology.
Clark MG, Beinlich CJ, McKee EE, Lins JA, Morgan HE (1980). Relationship between alkaline proteolytic activity and protein degradation in rat heart. Federation proceedings.
McKee EE, Clark MG, Beinlich CJ, Lins JA, Morgan HE (1979). Neutral-alkaline proteases and protein degradation in rat heart. Journal of molecular and cellular cardiology.
McKee EE, Cheung JY, Rannels DE, Morgan HE (1978). Measurement of the rate of protein synthesis and compartmentation of heart phenylalanine. The Journal of biological chemistry.
Liu DK, McKee EE, Fritz PJ (1976). Transfer RNA and aminoacyl transfer RNA in developing rats. Biology of the neonate.
Liu DK, McKee EE, Fritz PJ (1975). Increase in rat liver ribonuclease inhibitor levels during the neonatal period. Growth.
Credentials, Certifications & Awards
Trustee Teaching Award
Excellence in Teaching Award
Excellence in Teaching Foundational Science
Fellow of College of Medicine Academy of Medical Education
Outstanding Service and Committment to the UMDF Medical and Scientific Advisory Board
!st place - Mentor of Student Research Poster
Recognition of merit for service on Grant Review committee and Basic Science Reseaerch Counsel
President Geral R. Ford Feasibility Grant of the American Diabetes Association
1st Place - Mentor of Student Research Poster
Education
B.S., Pennsylvania State University,, University Park, Pennsylvania (PA)
Membership in Professional Organizations
Mitochondrial Medicine Society
American Society for Biochemistry and Molecular Biology
United Mitochondrial Disease Foundation
Association of Biochemistry Course Directors
American Heart Association, Council on Basic Science
Team-Based Learning Cooperative
International Association of Medical Science Educators
International Society of Nucleic Acid Research
American Association Advancement of Science
American Society for Cell Biology
American Diabetes Association