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MCKEE, EDWARD

Ph.D.

Professor with Tenure

Biography

Dr. Ed McKee is a biochemist specializing in mitochondrial metabolism and biogenesis and is an expert in the pedagogy of Team-Based-Learning. He joined CMED in 2011 as the Chair of Foundational Sciences and Professor of Biochemistry and Medical Genetics. He was appointed Interim Senior Associate Dean of Research, Administration, and Faculty Affairs in 2014 and Senior Associate Dean of Research in 2016; a position he still holds today. Dr. McKee teaches biochemistry and genetics throughout the curriculum and is currently a Co-Course Director of the Gastrointestinal Course. Edward McKee received B. S. degrees in Biology and Biochemistry from Pennsylvania State University in University Park, PA. He received his Ph. D. degree in physiology from the M. S. Hershey Medical Center, College of Medicine, Penn State University. His graduate work involved studies on the regulation of protein metabolism in the perfused rat heart. Following post-doctoral fellowships in the Department of Microbiology at the University of Connecticut Health Science Center in Farmington, Ct and in the Department of Molecular, Cellular, and Developmental Biology at the University of Colorado in Boulder, Dr. McKee took a faculty position in the Department of Biochemistry at what now is the Rosalind Franklin University of Health Science / The Chicago Medical School. Dr. McKee is active in the Team-Based Learning community and has given workshops on Team-Based learning at National and International meetings as well as at Universities and Medical Schools. He has served as treasurer and a member of the Executive committee of the Team Based Learning Collaborative. Dr. McKee also served as Vice-President of the Association of Biochemistry Educators (ABE), a group dedicated to supporting and enhancing the teaching of Biochemistry in medical, dental, and pharmacy schools. Dr. McKee's present laboratory research is on understanding the mitochondrial toxicity associated with several important classes of drugs. In a project funded by grants from the National Heart Lung and Blood Institute of the NIH, Dr. McKee’s laboratory studies the toxicity of anti-viral nucleoside analogs such as AZT used in the treatment of AIDS. In earlier work funded by pharmaceutical companies, Dr. McKee’s group studied the toxicity of antibiotics of the oxazolidinone family as represented by the FDA approved drug linezolid (Zyvox©).

More about Edward Mckee

Edward E. McKee, Selma Omer (2011). Protein Structure in Medicine” A Team-Based Learning Exercise MedEdPortal.

Lynx MD, LaClair DD, McKee EE (2009). Effects of zidovudine and stavudine on mitochondrial DNA of differentiating 3T3-F442a cells are not associated with imbalanced deoxynucleotide pools. Antimicrobial agents and chemotherapy.

McKee EE, Bentley AT, Hatch M, Gingerich J, Susan-Resiga D (2004). Phosphorylation of thymidine and AZT in heart mitochondria: elucidation of a novel mechanism of AZT cardiotoxicity. Cardiovascular toxicology.

Olivero OA, Vazquez IL, Cooch CC, Ming J, Keller E, Yu M, Borojerdi JP, Braun HM, McKee E, Poirier MC (2010). Long-term AZT exposure alters the metabolic capacity of cultured human lymphoblastoid cells. Toxicological sciences : an official journal of the Society of Toxicology.

McCann KA, Williams DW, McKee EE (2012). Metabolism of deoxypyrimidines and deoxypyrimidine antiviral analogs in isolated brain mitochondria. Journal of neurochemistry.

Morris GW, Iams TA, Slepchenko KG, McKee EE (2009). Origin of pyrimidine deoxyribonucleotide pools in perfused rat heart: implications for 3'-azido-3'-deoxythymidine-dependent cardiotoxicity. The Biochemical journal.

Lynx MD, Kang BK, McKee EE (2008). Effect of AZT on thymidine phosphorylation in cultured H9c2, U-937, and Raji cell lines. Biochemical pharmacology.

Morris GW, Laclair DD, McKee EE (2010). Pyrimidine deoxynucleoside and nucleoside reverse transcriptase inhibitor metabolism in the perfused heart and isolated mitochondria. Antiviral therapy.

Kamath VG, Hsiung CH, Lizenby ZJ, McKee EE (2015). Heart mitochondrial TTP synthesis and the compartmentalization of TMP. The Journal of biological chemistry.

McHenry P, Wang WL, Devitt E, Kluesner N, Davisson VJ, McKee E, Schweitzer D, Helquist P, Tenniswood M (2010). Iejimalides A and B inhibit lysosomal vacuolar H+-ATPase (V-ATPase) activity and induce S-phase arrest and apoptosis in MCF-7 cells. Journal of cellular biochemistry.

Donnino MW, Miller J, Garcia AJ, McKee E, Walsh M (2007). Distinctive acid-base pattern in Wernicke's encephalopathy. Annals of emergency medicine.

Lynx MD, McKee EE (2006). 3'-Azido-3'-deoxythymidine (AZT) is a competitive inhibitor of thymidine phosphorylation in isolated rat heart and liver mitochondria. Biochemical pharmacology.

Flanagan S, McKee EE, Das D, Tulkens PM, Hosako H, Fiedler-Kelly J, Passarell J, Radovsky A, Prokocimer P (2015). Nonclinical and pharmacokinetic assessments to evaluate the potential of tedizolid and linezolid to affect mitochondrial function. Antimicrobial agents and chemotherapy.

Susan-Resiga D, Bentley AT, Lynx MD, LaClair DD, McKee EE (2007). Zidovudine inhibits thymidine phosphorylation in the isolated perfused rat heart. Antimicrobial agents and chemotherapy.

Snowdin JW, Hsiung CH, Kesterson DG, Kamath VG, McKee EE (2015). Effects of Zidovudine Treatment on Heart mRNA Expression and Mitochondrial DNA Copy Number Associated with Alterations in Deoxynucleoside Triphosphate Composition in a Neonatal Rat Model. Antimicrobial agents and chemotherapy.

Xi J, Si XA, Kim J, Mckee E, Lin EB (2014). Exhaled aerosol pattern discloses lung structural abnormality: a sensitivity study using computational modeling and fractal analysis. PloS one.

Lynx MD, Bentley AT, McKee EE (2006). 3'-Azido-3'-deoxythymidine (AZT) inhibits thymidine phosphorylation in isolated rat liver mitochondria: a possible mechanism of AZT hepatotoxicity. Biochemical pharmacology.

Poyton RO, Bellus G, McKee EE, Sevarino KA, Goehring B (1996). In organello mitochondrial protein and RNA synthesis systems from Saccharomyces cerevisiae. Methods in enzymology.

Madariaga MG, Swindells S, McKee EE (2007). Oxazolidinones and human immunodeficiency virus. Antimicrobial agents and chemotherapy.

Liu DK, McKee EE, Fritz PJ (1975). Increase in rat liver ribonuclease inhibitor levels during the neonatal period. Growth.

McKee EE, Grier BL (1990). Insulin stimulates mitochondrial protein synthesis and respiration in isolated perfused rat heart. The American journal of physiology.

McKee EE, McEwen JE, Poyton RO (1984). Mitochondrial gene expression in saccharomyces cerevisiae. II. Fidelity of translation in isolated mitochondria from wild type and respiratory-deficient mutant cells. The Journal of biological chemistry.

McKee EE, Cheung JY, Rannels DE, Morgan HE (1978). Measurement of the rate of protein synthesis and compartmentation of heart phenylalanine. The Journal of biological chemistry.

Clark MG, Beinlich CJ, McKee EE, Lins JA, Morgan HE (1980). Relationship between alkaline proteolytic activity and protein degradation in rat heart. Federation proceedings.

Beinlich CJ, Clark MG, McKee EE, Lins JA, Morgan HE (1981). Neutral-alkaline proteolytic activity in rat cardiac muscle cells. Journal of molecular and cellular cardiology.

Leung AC, McKee EE (1990). Mitochondrial protein synthesis during thyroxine-induced cardiac hypertrophy. The American journal of physiology.

Czerwinski SM, Kurowski TT, McKee EE, Zak R, Hickson RC (1991). Myosin heavy chain turnover during cardiac mass changes by glucocorticoids. Journal of applied physiology (Bethesda, Md. : 1985).

McKee EE, Grier BL, Thompson GS, Leung AC, McCourt JD (1990). Coupling of mitochondrial metabolism and protein synthesis in heart mitochondria. The American journal of physiology.

McKee EE, Bentley AT, Smith RM Jr, Kraas JR, Ciaccio CE (2000). Guanine nucleotide transport by atractyloside-sensitive and -insensitive carriers in isolated heart mitochondria. American journal of physiology. Cell physiology.

McKee EE, Grier BL, Thompson GS, McCourt JD (1990). Isolation and incubation conditions to study heart mitochondrial protein synthesis. The American journal of physiology.

McKee EE, Poyton RO (1984). Mitochondrial gene expression in saccharomyces cerevisiae. I. Optimal conditions for protein synthesis in isolated mitochondria. The Journal of biological chemistry.

McKee EE (1994). Mitochondrial gene expression in Saccharomyces cerevisiae. IV. Effects of yeast cytosol on mitochondrial protein synthesis, degradation, and respiration. Biochimica et biophysica acta.

Czerwinski SM, McKee EE, Hickson RC (1989). Glucocorticoid receptor activation in isolated perfused rat hearts. The American journal of physiology.

McKee EE, Ferguson M, Bentley AT, Marks TA (2006). Inhibition of mammalian mitochondrial protein synthesis by oxazolidinones. Antimicrobial agents and chemotherapy.

McKee EE, Clark MG, Beinlich CJ, Lins JA, Morgan HE (1979). Neutral-alkaline proteases and protein degradation in rat heart. Journal of molecular and cellular cardiology.

Liu DK, McKee EE, Fritz PJ (1976). Transfer RNA and aminoacyl transfer RNA in developing rats. Biology of the neonate.

Black-Schaefer CL, McCourt JD, Poyton RO, McKee EE (1991). Mitochondrial gene expression in Saccharomyces cerevisiae. Proteolysis of nascent chains in isolated yeast mitochondria optimized for protein synthesis. The Biochemical journal.

McKee EE, Bentley AT, Smith RM Jr, Ciaccio CE (1999). Origin of guanine nucleotides in isolated heart mitochondria. Biochemical and biophysical research communications.

Avery Ward, Chia-Henry Hsiung, Daniel Kesterson, Vasudeva Kamath, Edward E. McKee (2022). Entecavir competitively inhibits deoxyguanosine and deoxyadenosine phosphorylation in isolated mitochondria and the perfused rat heart. Journal of Biological Chemistry.

Edward E. McKee, Selma Omer (2011). Applying Thermodynamics, Enzyme Kinetics, and pH in Medical Biochemistry” - a Team-Based Learning Exercise MedEdPortal.

Edward E. McKee (2011). Team Based Learning Exercise “Risk Analysis in Genetics” MedEdPortal.

Edward E. McKee, George W. Knowles, W. Marshall Andersen (2010). Team-Based Learning Exercise -Nutrition and Metabolism: “The Hunger Strike” MedEdPortal.
Fellow of College of Medicine Academy of Medical Education
President Geral R. Ford Feasibility Grant of the American Diabetes Association
Recognition of merit for service on Grant Review committee and Basic Science Reseaerch Counsel
!st place - Mentor of Student Research Poster
Outstanding Basic Science Professor
1st Place - Mentor of Student Research Poster
Trustee Teaching Award
Outstanding Service and Committment to the UMDF Medical and Scientific Advisory Board
Excellence in Teaching Award
Excellence in Teaching Foundational Science
Ph.D., Pennsylvania State University-College of Medicine
B.S., Pennsylvania State University,, University Park, Pennsylvania (PA)
Mitochondrial Medicine Society
Association of Biochemistry Course Directors
American Heart Association, Council on Basic Science
United Mitochondrial Disease Foundation
American Society for Biochemistry and Molecular Biology
Team-Based Learning Cooperative
American Society for Cell Biology
International Association of Medical Science Educators
American Society for Microbiology
American Association Advancement of Science
International Society of Nucleic Acid Research
American Diabetes Association