Chu, Roland
M.D.
Program Director
Associate Professor
Clinical Associate Professor
Clinical Associate Professor
More about Roland Chu
Publications & Presentations
Maxim Yankelevich, Archana Thakur, Shakeel Modak, Roland Chu, Jeffrey Taub, Alissa Martin, Amy Schienshang, Sarah Whitaker, Katie Rea, Daniel W Lee, Qin Liu, Anthony F Shields, Nai-Kong V Cheung, Lawrence G Lum (2024). Targeting refractory/recurrent neuroblastoma and osteosarcoma with anti-CD3xanti-GD2 bispecific antibody armed T cells. Journal for Immunotherapy of Cancer.
Parekh D, Lin H, Batajoo A, Peckham-Gregory E, Karri V, Stanton W, Scull B, Fleishmann R, El-Mallawany N, Eckstein OS, Prudowsky ZD, Gulati N, Agrusa J, Ahmed AZ, Chu R, Dietz MS, Goldman SC, Hogarty MD, Imran H, Intzes S, Kim JM, Kopp LM, Levy CF, Neff P, Pillai PM, Sisk BA, Schiff DE, Trobaugh-Lotrario AD, Walkovich K, McClain, K, Allen CE (2024). Clofarabine mono therapy in aggressive, relapsed and refractory Langerhans cell histiocytosis British Journal of Haematology.
Zalewski K, Cantor E, Chu R, Mody R, Yanik G, Sedig L (2024). Concurrent primary mediastinal germ cell tumor and acute myeloid leukemia: Case report of sustained remission and review of literature Pediatric Blood and Cancer.
Prahlad Parajuli, Douglas B Craig, Manisha Gadgeel, Shruti Bagla, Robert E Wright 3rd, Roland Chu, Christina M Shanti, Rajeev Thirunagari, Yaddanapudi Ravindranath (2023). Defective monocyte plasticity and altered cAMP pathway characterize USB1-mutated poikiloderma with neutropenia Clericuzio type British Journal of Hematology.
Al-Antary ET, Henry M, Spruit J, Yankelevich M, Chu R, Ravindranath Y, Savasan S (2021). Patterns and correlates of preserved humoral immunity to vaccines in children following allogeniec hematopoietic stem cell transplantation Pediatr Transplant.
Yankelevich M, Hoogstra DJ, Abrams J, Chu, R, Bhambhani K, Taub JW (2020). Delayed Granulocyte Colony-Stimulating Factor (G_CSF) administration after Chemotherapy Reduces Total G-CSF Doses without affecting neutrophil recovery in a randomized clinical study in children with solid tumors Pediatric Hematology Oncology.
Rayner P, Spruit JL, Chu R, Yankelevich M, Henry M, Ravindranath Y, Savasan S (2019). Role of Initiating Supportive Care Preceding Veno-occlusive Disease Diagnosis Following Allogeneic Hematopoietic Stem Cell Transplantation in Children. Journal of Pediatric Hematology Oncology.
Eckstein OS, Visser J, Rodriguez-Galindo C, Allen CE, NACHO-LIBRE Study Group (2019). Clinical responses and persistent BRAF V600E+ blood cells in children with LCH treated with MAPL pathway inhibition Blood.
Covi S, Ravindranath Y, Farooqi A, Savasan R, Chu R, Aggarwal S (2018). Changes in Bi-ventricular Function After Hematopoietic Stem Cell Transplant as Assessed by Speckle Tracking Echocardiography Pediatric Cardiology.
McGrath E, Abdel-Haq N, Asmar B, Chu R, Rajpurkar M (2018). Ethanol Lock for CLABSI in children with cancer: a matter of (dwell) time? The Lancet Infectious Diseases.
Yankelevich M, Savasan S, Dolgopolov I, Chu R, Mentkevich G (2017). Small Split Doses of CD34Peripheral Blood Stem Cells to Support Repeated Cycles of Nonmyeloablative Chemotherapy Case Reports in Oncological Medicine.
Ma J, Li X, Su Y, Zhao J, Luedtke DA, Epshteyn V, Edwards H, Wang G, Wang Z, Chu R, Taub JW, Lin H, Wang Y, Ge Y (2017). Mechanisms responsible for the synergistic antileukemic interactions between ATR inhibition and cytarabine in acute myeloid leukemia cells. Scientific Reports.
Cashen K, Chu RL, Klein J, Rycus PT, Costello JM (2017). Extracorporeal membrane oxygenation outcomes in children with hemophagocytic lymphohistiocytosis. Perfusion.
Yankelevich M, Savasan S, Dolgopolov I, Chu R, Mentkevich G (2017). Small Split Doses of CD34(+) Peripheral Blood Stem Cells to Support Repeated Cycles of Nonmyeloablative Chemotherapy. Case reports in oncological medicine.
Ma J, Li X, Su Y, Zhao J, Luedtke DA, Epshteyn V, Edwards H, Wang G, Wang Z, Chu R, Taub JW, Lin H, Wang Y, Ge Y (2017). Mechanisms responsible for the synergistic antileukemic interactions between ATR inhibition and cytarabine in acute myeloid leukemia cells. Scientific reports.
Cashen K, Chu RL, Klein J, Rycus PT, Costello JM (2016). Extracorporeal membrane oxygenation outcomes in children with hemophagocytic lymphohistiocytosis. Perfusion (United Kingdom).
Niu X, Zhao J, Ma J, Xie C, Edwards H, Wang G, Caldwell JT, Chu R, Xiang S, Zhang X, Chu R, Wang JW, Lin H, Taub JW, GE Y (2016). Binding of released bim to Mcl-1 is a mechanism of intrinsic resistance to ABT-199 which can be overcome by combination with daunorubicin or cytarabine in AML cells Clinical Cancer Research.
Edwards H, Rubenstein M, Dombkowski AA, Caldwell JT, Chu R, Xavier AC, Hummel R, Neely M, Matherly LH, Ge Y, Taub JW (2016). Gene Signature of High White Blood Cell Count in B-Precursor Acute Lymphoblastic Leukemia PLoS one.
Leitch CS, Natafji E, Yu C, Abdul-Ghaffar S, Madarasingha N, Venables ZC, Chu R, Fitch PM, Muinonen-Martin AJ, Campbell LE, McLean WH, Schwarze J, Howie SE, Weller RB (2016). Filaggrin-null mutations are associated with increased maturation markers on Langerhans cells. The Journal of allergy and clinical immunology.
Qi W, Zhang W, Edwards H, Chu R, Madlambayan GJ, Taub JW, Wang Z, Wang Y, Li C, Lin H, Ge Y (2015). Synergistic anti-leukemic interactions between panobinostat and MK-1775 in acute myeloid leukemia ex vivo Cancer Biology & Therapy.
Parsons HM, Harlan LC, Schmidt S, Keegan THM, Lynch CF, Kent EE, Wu XC, Schwartz SM, Chu RL, Keel G, Smith AW (2015). Who treats adolescents and young adults with cancer? A report from the AYA HOPE study Journal of Adolescent and Young Adult Oncology.
Keegan TH, Tao L, DeRouen MC, Wu XC, Prasad P, Lynch CF, Shnorhavorian M, Zebeck BJ, Chu R, Harlan LC, Smith AW, Parsons HM (2014). Medical care in adolescents and young adult cancer survivors: What are the biggest access-related barriers? Journal of Cancer Survivorship.
Chaudhary M, Bilal MF, Du W, Chu R, Rajpurkar M, McGrath EJ (2014). The impact of ethanol lock therapy on length of stay and catheter salvage in pediatric catheter-associated bloodstream infection Clinical Pediatrics.
Chaudhary M, Bilal MF, Du W, Chu R, Rajpurkar M, McGrath EJ (2014). The impact of ethanol lock therapy on length of stay and catheter salvage in pediatric catheter-associated bloodstream infection. Clinical pediatrics.
Jesudas R, Malesky A, Chu R, Fischer H, Kamat D (2013). Reviewing the follow-up care of pediatric patients’ status post-hematopoietic stem cell transplantation for the primary care pediatrician Clinical Pediatrics.
Paximadis P, Hallock A, Bhambhani K, Chu R, Sood S, Wang Z, Konski A (2012). Patterns of failure in patients with primary intracranial germinoma treated with neoadjuvant chemotherapy and radiotherapy Pediatric Neurology.
McGrath EJ, Salloum R, Chen X, Jiang Y, Boldt-MacDonald K, Becker C, Chu R, Ang JY (2011). Short-dwell ethanol lock therapy in children is associated with increased clearance of central line-associated bloodstream infections Clinical Pediatrics.
Marshall C, Boldt-MacDonald K, McLenon R, Rennie E, Faraon, M, Conoff S, Lesnek J, Becker C, Chu R (2011). A Multidisciplinary Approach to Determine Heparin Dosing in Pediatric Vascular Devices Journal of Pediatric Oncology Nursing.
Chu R, Brazauskas R, Kan F, Bashey A, Bredeson C, Camitta B, Chiang KY, Frangoul H, Gale RP, Gee A, George B, Goldman FD, Gross TG, Gupta V, Hale GA, Isola L, Ispizua AU, Lazarus H, Marsh J, Russell J, Sabloff M, Waller EK, Eapen M (2011). Comparison of outcomes after transplantation of G-CSF-stimulated bone marrow grafts versus bone marrow or peripheral blood grafts from HLA-matched sibling donors for patients with severe aplastic anemia Biology of Bood and Marrow Transplantation: Journal of the American Society for Blood and Marrow Transplantation.
McGrath EJ, Salloum R, Chen X, Jiang Y, Boldt-MacDonald K, Becker C, Chu R, Ang JY (2011). Short-dwell ethanol lock therapy in children is associated with increased clearance of central line-associated bloodstream infections. Clinical pediatrics.
Naji Z, Rajpurkar M, Savasan S, Chu R, Chitlur M, Callaghan M (2010). Mycophenolate Mofetil Therapy Is a Steroid Sparing In Childhood and Young Adult Chronic ITP and Evans Syndrome Blood.
Hijiya N, Gaynon P, Barry E, Silverman L, Thomson B, Chu R, Cooper T, Kadota R, Rytting M, Steinherz P, Shen V, Jeha S, Abichandani R, Carroll WL (2009). A multi-center phase i study of clofarabine, etoposide and cyclophosphamide in combination in pediatric patients with refractory or relapsed acute leukemia. Leukemia.
Howell DL, Bergsagel J, Chu R, Meachem, L (2004). Suppression of Hodgkin’s Disease in a Patient with Cushing's Syndrome Journal of Pediatric Hematology/Oncology.
Chu RL, Post DE, Khuri FR, Van Meir EG (2004). Use of replicating oncolytic adenoviruses in combination therapy for cancer Clinical Cancer Research.
AlQanber, Chu, Battisti (). Cancer.Net: Guides to Cancer Care Journal of Consumer Health on the Internet.
Parekh D, Lin H, Batajoo A, Peckham-Gregory E, Karri V, Stanton W, Scull B, Fleishmann R, El-Mallawany N, Eckstein OS, Prudowsky ZD, Gulati N, Agrusa J, Ahmed AZ, Chu R, Dietz MS, Goldman SC, Hogarty MD, Imran H, Intzes S, Kim JM, Kopp LM, Levy CF, Neff P, Pillai PM, Sisk BA, Schiff DE, Trobaugh-Lotrario AD, Walkovich K, McClain, K, Allen CE (2024). Clofarabine mono therapy in aggressive, relapsed and refractory Langerhans cell histiocytosis British Journal of Haematology.
Zalewski K, Cantor E, Chu R, Mody R, Yanik G, Sedig L (2024). Concurrent primary mediastinal germ cell tumor and acute myeloid leukemia: Case report of sustained remission and review of literature Pediatric Blood and Cancer.
Prahlad Parajuli, Douglas B Craig, Manisha Gadgeel, Shruti Bagla, Robert E Wright 3rd, Roland Chu, Christina M Shanti, Rajeev Thirunagari, Yaddanapudi Ravindranath (2023). Defective monocyte plasticity and altered cAMP pathway characterize USB1-mutated poikiloderma with neutropenia Clericuzio type British Journal of Hematology.
Al-Antary ET, Henry M, Spruit J, Yankelevich M, Chu R, Ravindranath Y, Savasan S (2021). Patterns and correlates of preserved humoral immunity to vaccines in children following allogeniec hematopoietic stem cell transplantation Pediatr Transplant.
Yankelevich M, Hoogstra DJ, Abrams J, Chu, R, Bhambhani K, Taub JW (2020). Delayed Granulocyte Colony-Stimulating Factor (G_CSF) administration after Chemotherapy Reduces Total G-CSF Doses without affecting neutrophil recovery in a randomized clinical study in children with solid tumors Pediatric Hematology Oncology.
Rayner P, Spruit JL, Chu R, Yankelevich M, Henry M, Ravindranath Y, Savasan S (2019). Role of Initiating Supportive Care Preceding Veno-occlusive Disease Diagnosis Following Allogeneic Hematopoietic Stem Cell Transplantation in Children. Journal of Pediatric Hematology Oncology.
Eckstein OS, Visser J, Rodriguez-Galindo C, Allen CE, NACHO-LIBRE Study Group (2019). Clinical responses and persistent BRAF V600E+ blood cells in children with LCH treated with MAPL pathway inhibition Blood.
Covi S, Ravindranath Y, Farooqi A, Savasan R, Chu R, Aggarwal S (2018). Changes in Bi-ventricular Function After Hematopoietic Stem Cell Transplant as Assessed by Speckle Tracking Echocardiography Pediatric Cardiology.
McGrath E, Abdel-Haq N, Asmar B, Chu R, Rajpurkar M (2018). Ethanol Lock for CLABSI in children with cancer: a matter of (dwell) time? The Lancet Infectious Diseases.
Yankelevich M, Savasan S, Dolgopolov I, Chu R, Mentkevich G (2017). Small Split Doses of CD34Peripheral Blood Stem Cells to Support Repeated Cycles of Nonmyeloablative Chemotherapy Case Reports in Oncological Medicine.
Ma J, Li X, Su Y, Zhao J, Luedtke DA, Epshteyn V, Edwards H, Wang G, Wang Z, Chu R, Taub JW, Lin H, Wang Y, Ge Y (2017). Mechanisms responsible for the synergistic antileukemic interactions between ATR inhibition and cytarabine in acute myeloid leukemia cells. Scientific Reports.
Cashen K, Chu RL, Klein J, Rycus PT, Costello JM (2017). Extracorporeal membrane oxygenation outcomes in children with hemophagocytic lymphohistiocytosis. Perfusion.
Yankelevich M, Savasan S, Dolgopolov I, Chu R, Mentkevich G (2017). Small Split Doses of CD34(+) Peripheral Blood Stem Cells to Support Repeated Cycles of Nonmyeloablative Chemotherapy. Case reports in oncological medicine.
Ma J, Li X, Su Y, Zhao J, Luedtke DA, Epshteyn V, Edwards H, Wang G, Wang Z, Chu R, Taub JW, Lin H, Wang Y, Ge Y (2017). Mechanisms responsible for the synergistic antileukemic interactions between ATR inhibition and cytarabine in acute myeloid leukemia cells. Scientific reports.
Cashen K, Chu RL, Klein J, Rycus PT, Costello JM (2016). Extracorporeal membrane oxygenation outcomes in children with hemophagocytic lymphohistiocytosis. Perfusion (United Kingdom).
Niu X, Zhao J, Ma J, Xie C, Edwards H, Wang G, Caldwell JT, Chu R, Xiang S, Zhang X, Chu R, Wang JW, Lin H, Taub JW, GE Y (2016). Binding of released bim to Mcl-1 is a mechanism of intrinsic resistance to ABT-199 which can be overcome by combination with daunorubicin or cytarabine in AML cells Clinical Cancer Research.
Edwards H, Rubenstein M, Dombkowski AA, Caldwell JT, Chu R, Xavier AC, Hummel R, Neely M, Matherly LH, Ge Y, Taub JW (2016). Gene Signature of High White Blood Cell Count in B-Precursor Acute Lymphoblastic Leukemia PLoS one.
Leitch CS, Natafji E, Yu C, Abdul-Ghaffar S, Madarasingha N, Venables ZC, Chu R, Fitch PM, Muinonen-Martin AJ, Campbell LE, McLean WH, Schwarze J, Howie SE, Weller RB (2016). Filaggrin-null mutations are associated with increased maturation markers on Langerhans cells. The Journal of allergy and clinical immunology.
Qi W, Zhang W, Edwards H, Chu R, Madlambayan GJ, Taub JW, Wang Z, Wang Y, Li C, Lin H, Ge Y (2015). Synergistic anti-leukemic interactions between panobinostat and MK-1775 in acute myeloid leukemia ex vivo Cancer Biology & Therapy.
Parsons HM, Harlan LC, Schmidt S, Keegan THM, Lynch CF, Kent EE, Wu XC, Schwartz SM, Chu RL, Keel G, Smith AW (2015). Who treats adolescents and young adults with cancer? A report from the AYA HOPE study Journal of Adolescent and Young Adult Oncology.
Keegan TH, Tao L, DeRouen MC, Wu XC, Prasad P, Lynch CF, Shnorhavorian M, Zebeck BJ, Chu R, Harlan LC, Smith AW, Parsons HM (2014). Medical care in adolescents and young adult cancer survivors: What are the biggest access-related barriers? Journal of Cancer Survivorship.
Chaudhary M, Bilal MF, Du W, Chu R, Rajpurkar M, McGrath EJ (2014). The impact of ethanol lock therapy on length of stay and catheter salvage in pediatric catheter-associated bloodstream infection Clinical Pediatrics.
Chaudhary M, Bilal MF, Du W, Chu R, Rajpurkar M, McGrath EJ (2014). The impact of ethanol lock therapy on length of stay and catheter salvage in pediatric catheter-associated bloodstream infection. Clinical pediatrics.
Jesudas R, Malesky A, Chu R, Fischer H, Kamat D (2013). Reviewing the follow-up care of pediatric patients’ status post-hematopoietic stem cell transplantation for the primary care pediatrician Clinical Pediatrics.
Paximadis P, Hallock A, Bhambhani K, Chu R, Sood S, Wang Z, Konski A (2012). Patterns of failure in patients with primary intracranial germinoma treated with neoadjuvant chemotherapy and radiotherapy Pediatric Neurology.
McGrath EJ, Salloum R, Chen X, Jiang Y, Boldt-MacDonald K, Becker C, Chu R, Ang JY (2011). Short-dwell ethanol lock therapy in children is associated with increased clearance of central line-associated bloodstream infections Clinical Pediatrics.
Marshall C, Boldt-MacDonald K, McLenon R, Rennie E, Faraon, M, Conoff S, Lesnek J, Becker C, Chu R (2011). A Multidisciplinary Approach to Determine Heparin Dosing in Pediatric Vascular Devices Journal of Pediatric Oncology Nursing.
Chu R, Brazauskas R, Kan F, Bashey A, Bredeson C, Camitta B, Chiang KY, Frangoul H, Gale RP, Gee A, George B, Goldman FD, Gross TG, Gupta V, Hale GA, Isola L, Ispizua AU, Lazarus H, Marsh J, Russell J, Sabloff M, Waller EK, Eapen M (2011). Comparison of outcomes after transplantation of G-CSF-stimulated bone marrow grafts versus bone marrow or peripheral blood grafts from HLA-matched sibling donors for patients with severe aplastic anemia Biology of Bood and Marrow Transplantation: Journal of the American Society for Blood and Marrow Transplantation.
McGrath EJ, Salloum R, Chen X, Jiang Y, Boldt-MacDonald K, Becker C, Chu R, Ang JY (2011). Short-dwell ethanol lock therapy in children is associated with increased clearance of central line-associated bloodstream infections. Clinical pediatrics.
Naji Z, Rajpurkar M, Savasan S, Chu R, Chitlur M, Callaghan M (2010). Mycophenolate Mofetil Therapy Is a Steroid Sparing In Childhood and Young Adult Chronic ITP and Evans Syndrome Blood.
Hijiya N, Gaynon P, Barry E, Silverman L, Thomson B, Chu R, Cooper T, Kadota R, Rytting M, Steinherz P, Shen V, Jeha S, Abichandani R, Carroll WL (2009). A multi-center phase i study of clofarabine, etoposide and cyclophosphamide in combination in pediatric patients with refractory or relapsed acute leukemia. Leukemia.
Howell DL, Bergsagel J, Chu R, Meachem, L (2004). Suppression of Hodgkin’s Disease in a Patient with Cushing's Syndrome Journal of Pediatric Hematology/Oncology.
Chu RL, Post DE, Khuri FR, Van Meir EG (2004). Use of replicating oncolytic adenoviruses in combination therapy for cancer Clinical Cancer Research.
AlQanber, Chu, Battisti (). Cancer.Net: Guides to Cancer Care Journal of Consumer Health on the Internet.
Credentials, Certifications & Awards
Top Doc List Pediatric Oncology. Metropolitan Detroit's entertainment magazine. Annual nominations are made by peers and community physicians. This is an annual award list of Top Docs in the Metropolitan Detroit area.
Top Doc List Pediatric Oncology. Metropolitan Detroit's entertainment magazine. Annual nominations are made by peers and community physicians. This is an annual award list of Top Docs in the Metropolitan Detroit area.
Teaching Award
Mom Approved Doctors. Metro Parent Magazine is a regional magazine offering advice and support for parents in southeastern Michigan. Nominations are through parents experiences with these physicians.
Children's Hospital of MI Physician Difference Maker Award. Award given to 2 physicians per month at DMC Children' Hospital of MI for their service to the patients, and to the hospital.
Detroit Super Doctors. Super Doctors is a listing of outstanding doctors from more than 40 medical specialties who have attained a high degree of peer recognition or professional development. It is published as a special suplement in leading newspapers and city and regional magazines. The list comprises approximately 5% of the physicians within the respective state or region.
Top Doc List Pediatric Oncology. Metropolitan Detroit's entertainment magazine. Annual nominations are made by peers and community physicians. This is an annual award list of Top Docs in the Metropolitan Detroit area.
Teaching Award
Mom Approved Doctors. Metro Parent Magazine is a regional magazine offering advice and support for parents in southeastern Michigan. Nominations are through parents experiences with these physicians.
Children's Hospital of MI Physician Difference Maker Award. Award given to 2 physicians per month at DMC Children' Hospital of MI for their service to the patients, and to the hospital.
Detroit Super Doctors. Super Doctors is a listing of outstanding doctors from more than 40 medical specialties who have attained a high degree of peer recognition or professional development. It is published as a special suplement in leading newspapers and city and regional magazines. The list comprises approximately 5% of the physicians within the respective state or region.
Education
Residency, Children's Hospital Of Michigan/Wayne State University School of Medicine, Detroit, Michigan (MI)
B.S., University of Michigan-Ann Arbor, Ann Arbor, Michigan (MI)
Fellowship, Aflac Cancer and Blood Disorder Center/Emory University School of Medicine, Atlanta, Georgia (GA)
M.D., Wayne State University School of Medicine, Detroit, Michigan (MI)
B.S., University of Michigan-Ann Arbor, Ann Arbor, Michigan (MI)
Fellowship, Aflac Cancer and Blood Disorder Center/Emory University School of Medicine, Atlanta, Georgia (GA)
M.D., Wayne State University School of Medicine, Detroit, Michigan (MI)